缝隙连接蛋白43在脑缺血再灌注中的作用及其机制  

Roles and mechanisms of connexin 43 in cerebral ischemia-reperfusion

作　　者：李孔平 郑剑华 陈晓辉[1] 方敏华[1] 徐恩[1] Li Kongping;Zheng Jianhua;Chen Xiaohui;Fang Minhua;Xu En(Institute of Neurosciences,Department of Neurology,the Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260,China)

机构地区：[1]广州医科大学附属第二医院神经内科,广州医科大学神经科学研究所,510260

出　　处：《国际脑血管病杂志》2018年第9期708-716,共9页International Journal of Cerebrovascular Diseases

基　　金：广州市科技计划项目（201804010124）;国家自然科学基金（81501952,81501015）;广州市医学重点学科建设项目（2017-2019）

摘　　要：在中枢神经系统中,神经元与胶质细胞之间存在缝隙连接.其中,缝隙连接蛋白43（connexin43,Cx43）是中枢神经系统中含量最丰富的缝隙连接蛋白之一,参与细胞间物质交换的代谢偶联以及电信号传递的电偶联,对细胞新陈代谢、内环境稳态、细胞分化等生理过程具有重要调控作用.脑缺血后,缝隙连接失偶联及半通道活性异常引起细胞内外环境的稳态失衡,最终导致脑组织损伤.因此,维持Cx43的正常功能对于保护脑组织免受脑缺血再灌注诱导的神经元损伤至关重要.In the central nervous system, gap junctions exist between neurons and glial cells. Among them, connexin 43 （Cx43） is one of the most abundant connexin proteins in the central nervous system,involved in the metabolic coupling of intercellular substance exchange and electrical coupling of electrical signaling. It plays an important role in regulating cell metabolism, homeostasis, and cell differentiation. After cerebral ischemia, the uncoupling of gap junctions and abnormal hemichannel activity cause a steady-state imbalance of the internal and external environment of the cells, eventually leading to brain tissue damage.Therefore, maintaining the normal function of Cx43 is essential for protecting brain tissue from neuronal damage induced by cerebral ischemia-reperfusion.

关 键 词：脑缺血 再灌注损伤 缝隙连接 缝隙连接蛋白43 src家族激酶类 闭锁小带蛋白1 兴奋性氨基酸转运体2 离子通道 细胞死亡 神经保护 

分 类 号：R743[医药卫生—神经病学与精神病学]