沉默信息调节因子1在肝细胞癌中的研究进展  

Research progress of silent information regulator 1 in hepatocellular carcinoma

作　　者：党树伟 李国东[1] 刘明[1] Dang Shuwei;Li Guodong;Liu Ming(Department of General Surgery,Bio-Bank of Department of General Surgery,the Fourth Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第四医院普外科普外科生物样本库,哈尔滨150001

出　　处：《中华肝胆外科杂志》2018年第11期781-785,共5页Chinese Journal of Hepatobiliary Surgery

基　　金：国家自然科学基金（81372612,81302059）;哈尔滨市应用技术研究与开发资金（创新人才项目）（2017RAXXJ057）

摘　　要：原发性肝细胞癌（hepatocellular carcinoma, HCC）是世界最常见的恶性肿瘤之一。目前，HCC发生、发展的具体分子机制尚未阐明。沉默信息调节因子1（silent information regulator 1, SIRT1）是依赖于烟酰胺腺嘌呤二核苷酸（NAD＋）的组蛋白去乙酰化酶，参与代谢、氧化应激、遗传毒性、衰老及肿瘤形成等生物学过程。近年来，SIRT1在HCC发生、发展中的作用已引起广泛关注。SIRT1在HCC的演进过程中呈异常表达，并发挥癌基因作用。它主要通过微小RNA、腺苷酸活化蛋白激酶、Yes相关蛋白（YAP）、端粒酶、自噬、PI3K/Akt等多个分子通路影响HCC的增殖、凋亡、转移及化疗耐药性等，进而参与HCC的发生与发展。本文就SIRT1在HCC研究领域中的最新进展予以综述。Primary hepatocellular carcinoma （HCC） is one of the most common malignant tumors worldwide. At present, the molecular mechanism of the carcinogenesis and development of HCC have not been systematically elucidated. Silent information regulator 1 （SIRT1） is a histone deacetylase, which is dependent on nicotinamide adenine dinucleotide （NAD＋ ）. It is involved in many biological processes such as metabolism, oxidative stress, genotoxicity, aging and tumor formation. During the recent years, thefunction of SIRT1 in the carcinogenesis and progress of HCC has attracted wide attention. SIRT1 is abnormally expressed in the development of HCC, and acts as an oncogene. It promotes the proliferation, apoptosis, metastasis and chemotherapy resistance of HCC through multiple molecular pathways including microRNA, AMP-activated protein kinase, Yes-associated protein, telomerase, autophagy, PI3K/Akt and so on. In this article, we discussed the latest research progress of SIRT1 in HCC.

关 键 词：沉默信息调节因子1 肝细胞癌 信号 通路 预后 

分 类 号：R735.7[医药卫生—肿瘤]