感染后脑炎和多发性硬化患者临床随诊与影像学比较的研究  

A Comparative Study of Clinical and Imaging Features and Follow - up in the Patients with Postinfectious Encephalitis and Multiple Sclerosis

作　　者：许志恩[1] 赵斌[1] 李燕珍[1] 

机构地区：[1]广东医学院附属医院神经内科,524001

出　　处：《神经疾病与精神卫生》2002年第4期215-216,219,共3页Journal of Neuroscience and Mental Health

摘　　要：目的 探讨感染后脑炎(PIE)与多发性硬化(MS)的临床和影像学特点、疗效与预后及其发病机制。方法 对我科1995～2000年诊断为PIE和MS的临床表现、影像学改变、实验室检查结果及疗效和预后进行前瞻性比较研究。结果(1)两组病例在起病方式、发病年龄和性别方面无差异;(2)PIE组均为单发病时相,病灶局限在大脑半球脑室旁,MS组多为多发病时相,病灶分布在中枢神经系统各部位;两组患者的症状和体征与磁共振所见病灶相符;(3)PIE的疗效和预后明显优于MS(P<0.01)。结论 PIE和MS可能是发病机制不同的两种疾病,它们的疗效和预后亦明显不同。To study the clinical and imaging features, prognosis and pathogenesis of postinfectious encephalalitis and multiple sclerosis. Methods 19 cases of postinfectious encephalalitis and 23 cases of multiple sclerosis were prospectively investigated. Their clinical and imaging features, laboratory ex-aminations, and prognosis were compared. Results (1) There were no differences in the age, sex and their onsets. (2) The course of patients with PIE were monophase, it 's locuses were limited in one side or two side of brain, but the course of patients with MS were multiphase and their locuses were multiple lesions in the white matter of the CNS. The clinical symptoms and signs of PIE and MS are accord with the lesions on MRI. (3) The effect and prognosis of PIE were significantly better than that of MS. Conclusions The pathogenesis of PIE and MS may be different and their effect and prognosis are different too.

关 键 词：感染后脑炎 多发性硬化 核磁共振成像 预后 PIE MS 临床表现 治疗 

分 类 号：R744.51[医药卫生—神经病学与精神病学]