低聚异麦芽糖对模拟失重大鼠肠道益生菌以及钙代谢和骨矿盐密度影响的初步研究  

THE EFFECTS OF ISOMALTOOLIGOSACCHARIDE ON THE GUT PROBIOTICS AND FEMUR'S BMD AND CALCIUM METABOLISM IN SIMULATING WEIGHTLESSNESS RATS

作　　者：黄纪明[1] 白树民[1] 朱德兵[1] 李志霞[1] 洪建武[1] 姜晓 

机构地区：[1]北京航天医学工程研究所,北京100094 [2]南阳卫生学校附院消化科,473058

出　　处：《中国微生态学杂志》2002年第4期189-191,共3页Chinese Journal of Microecology

摘　　要：目的 :研究低聚异麦芽糖对模拟失重大鼠肠道益生菌的影响以及与骨钙代谢变化的关系。方法 :30只雄性 SD大鼠随机分为 3组 (每组 10只 ) FC组 :普通对照组 (饲喂普通饲料 ) ;SC组 :模拟失重对照组(饲喂普通饲料 ) ;SS组 :模拟失重低聚异麦芽糖组 (饲喂普通饲料 +低聚异麦芽糖 ) ,实验期 2 1d。结果 :SC组大鼠肠道益生菌 (主要是双歧杆菌和乳杆菌 )数量、饲料钙的表观吸收率、股骨骨密度 (BMD)、骨钙含量以及骨钙素 (BGP)的水平显著低于 FC组 ,而血钙水平明显高于 FC组 ;SS组大鼠肠道益生菌数量、饲料钙的表观吸收率、骨密度、骨钙含量以及骨钙素水平较 SC组高 ,血钙水平显著低于 SC组。结论 :低聚异麦芽糖可以促进模拟失重大鼠肠道益生菌的增殖 ,减少股骨骨质的丢失 ,提高股骨 BMD,增加骨形成 。Objective:To study the the effects of isomaltooligosaccharide on the changes of gut probiotics and the femur's BMD as well as the calcium metabolism in simulating weightlessness rats.Methods:30 male SD rats were divided into three groups:one normal control group(FC) and two simulating weightlessness groups by tail suspended model(SC and SS),group FC and SC fed normal diet,and the group SS fed with normal diet supplemented with 5%(w/w) isomaltooligosaccharide,all rats drank purity water ad libitum.Results:(1)the number of gut Bifidobacterium and Lactobacillus in group SC was markedly lower than the group FC and group SS;(2)In group SC,the apparent absorption rate of the dietary calcium,the calcium content of femur and the BGP in serum as well as the level of the femur's BMD were significantly lower,whereas the concentration of the serum calcium was notably higher than the group FC and the group SS.Conclusion:Isomaltooligosaccharide can facilitate gut probiotics's proliferation,stimulate the activity of osteocyte,and has a positive effect on bone loss and the BMD of femur in simulating weightlessness rats.

关 键 词：低聚异麦芽糖 模拟失重 大鼠 肠道益生菌 钙代谢 骨矿盐密度 血钙 骨钙素 表观吸收率 

分 类 号：R977[医药卫生—药品] R852.22[医药卫生—药学]