^(131)I-肝癌单抗片段HAb18F(ab')_2注射液药盒的制备  

Preparation of ^(131)I Labeled Hepatoma Monoclonal Antibody Fragment HAb18F(ab')_2 Kit

作　　者：冯强[1] 米力[1] 边惠洁[1] 余晓玲[1] 陈志南[1] 

机构地区：[1]第四军医大学细胞工程研究中心,陕西西安710032

出　　处：《同位素》2002年第3期137-140,共4页Journal of Isotopes

基　　金：国家863计划资助项目(102-09-01-02)

摘　　要：选择Mather高效碘标法(NBS法)制备应用于肝癌治疗的131I-肝癌单抗片段HAb18F(ab')2注射液药盒,确定并优化了冷药盒各组分的剂型、标记条件和纯化方法。制备出的药盒抗体标记物的放化纯度大于95%,整个标记过程可在10min内完成,10℃以下干燥处可保存两年以上,适于临床应用。The kit of 131IHAb18F(ab')2 for hepatoma radioimmunotherapy is prepared. The labeling condition using Mather's method(Iodination) to label hepatoma monoclonal antibody fragment HAb18F(ab')2 and the purification method, as well the form of the kit are optimized. The whole process can be finished in 10 min. The radiochemical purity is more than 95%. The cold kit can be stored at dry surrounding below 10 ℃ no less than 2 years.

关 键 词：注射液 肝癌 HAb18F(ab')2 药盒 碘131 放射性核素 治疗 标记化合物 抗体 

分 类 号：R735.7[医药卫生—肿瘤] R730.55[医药卫生—临床医学]