由大鼠体内分布估算6-^(18)F-L-多巴在人体内的吸收剂量  

Estimation of Radiation Absorbed Doses for 6-^(18)F-L-DOPA in Human Based on Rats Biodistribution

作　　者：唐刚华[1] 张岚[2] 唐小兰 王明芳 罗磊 汪勇先[2] 黄祖汉 

机构地区：[1]第一军医大学南方医院南方中心,广东广州510515 [2]中国科学院上海原子核研究所放药中心,上海201800

出　　处：《同位素》2002年第3期164-167,共4页Journal of Isotopes

基　　金：国家"九五"重点科研项目(攻关)计划资助项目(96-B12-04-02-2);中国博士后科学基金资助项目;广东省自然科学基金资助项目(001104)

摘　　要：在大鼠尾静脉注射6-18F-L-多巴(18F-DOPA)后5、30、60、90、120和150min时处死动物,测定大鼠体内各脏器中18F活度分布,换算至标准人体内分布,按MIRD法估算人体18F-DOPA内照射吸收剂量。估算结果表明,肾脏的内照射吸收剂量最高,为22.9pGy/Bq,脑的内照射吸收剂量为11.8pGy/Bq,其它脏器的内照射吸收剂量为(9～18)pGy/Bq,有效剂量当量为20.5pSv/Bq。这表明,由大鼠体内分布资料可估算18F-DOPA在人体内的吸收剂量,为临床安全应用18F-DOPA提供了参考资料。To estimate the radiation absorbed doses in humans due to intravenous administration of 618FLDOPA(18FDOPA) based on rats biodistribution data and appraise the security of 18FDOPA in humans. At 5, 30, 60, 90, 120 and 150 min after 18FDOPA is injected into rats through a tail vein, the rats are killed by cervical fracture and biodistributions in rats are determined. Radiation dosimetry in humans are calculated on the base of activity distribution in rats and the standard MIRD method using radioactivitytime curves for humans. The kidney is the organ receiving highest dose of 22.9 pGy/Bq, the brain receives a dose of 11.8 pGy/Bq, and other organs receive doses between 9 and 18 pGy/Bq. The effective dose is estimated to be 20.5 pSv/Bq. The results demonstrate that human radiation dosimetry can be estimated by the rats biodistribution data and provide an important data for clinical safe trial of 18FDOPA .

关 键 词：6-^18F-L-多巴 体内生物分布 辐射吸收剂量 神经系统药物 放射性药物 安全性 

分 类 号：R817.51[医药卫生—影像医学与核医学] R817.91[医药卫生—放射医学]