喉癌患者性激素及分子细胞遗传学研究  

Sex hormone and molecular cytogenetics study on the case with laryngocarcinoma.

作　　者：王云英[1] 高岭[1] 魏红军[1] 赵书佑[1] 

机构地区：[1]青岛大学医学院附属青岛市市立医院遗传室,266011

出　　处：《中国优生与遗传杂志》2002年第4期36-38,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的　研究喉癌患者性激素及其性染色体改变。方法　采用放免法和荧光原位杂交 (FISH)技术。结果　 2 5例喉癌患者中 13例血清睾酮升高 ,9例雄激素升高 ,雌激素正常。 15例喉癌组织中 73 3%的病例呈现X染色体着丝粒拷贝增加 ,9例 (6 0 % )出现Y染色体丢失。结论　性激素及性染色体的改变在喉癌的发生发展中可能起重要作用。Objective: To study sex hormone change and chromosome aberration in the case of laryngocarcinoma. Methods: Radio immuno assay and fluorescence in situ hybridization technique were used. Results: In 25 patients there are 13 cases serum testosterone heightened and serum androgen increased in 9 cases. While serum estrogen was normal. Overpresentation of DXZ1 was detected in 73.3% cases and loss of chromosome Y was found in 60%(9/15) cases. Conclusion: Sex hormone and chromosome aberration may play an important role in the pathogenesis and growth of laryngocarcinoma.

关 键 词：喉癌 性激素 染色体 荧光原位杂交 

分 类 号：R739.65[医药卫生—肿瘤]