不伴有热带痉挛性瘫痪及HTLV-I相关脊髓病的HTLV-I感染性周围神经病  

Peripheral neuropathy in HTLV-I infected individuals without tropical spastic paraparesis/HTLV-I associated myelopathy

作　　者：Leite A.C.C. Silva M.T.T. Alamy A.H. A.Q.-C. Araújo 李锐 

机构地区：[1]Ctro. Referencia Neuroinfeccoes HTLV, Inst. Pesquisa Clin. Evandro Chagas, FIOCRUZ, Av. Brasil, 4365, Rio de Janeiro, RJ, 21045- 900, Brazil Dr.

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第1期15-15,共1页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Tropical spastic paraparesis/HTLV I associated myelopathy (TSP/HAM) is the classical neurological manifestation of HTLV I. Only a few studies have described isolated peripheral neuropathy (PN) among HTLV I infected individuals. 335 infected individuals without TSP/HAM were evaluated for the presence of PN and 45 of them showed evidences of peripheral nervous system involvement. Of these 21 patients had isolated PN, defined by clinical and/or electrophysiological criteria. Sural nerve biopsies revealed inflammatory infiltrates in 2, axonal degeneration in 2 and segmental demyelination in 1. Therefore, peripheral neuropathy can be found as an isolated manifestation of HTLV I infection. We conclude that HTLV I infection should be investigated in patients with PN of unknown origin.Tropical spastic paraparesis/HTLV I associated myelopathy (TSP/HAM) is the classical neurological manifestation of HTLV I. Only a few studies have described isolated peripheral neuropathy (PN) among HTLV I infected individuals. 335 infected individuals without TSP/HAM were evaluated for the presence of PN and 45 of them showed evidences of peripheral nervous system involvement. Of these 21 patients had isolated PN, defined by clinical and/or electrophysiological criteria. Sural nerve biopsies revealed inflammatory infiltrates in 2, axonal degeneration in 2 and segmental demyelination in 1. Therefore, peripheral neuropathy can be found as an isolated manifestation of HTLV I infection. We conclude that HTLV I infection should be investigated in patients with PN of unknown origin.

关 键 词：脊髓病 HTLV-I 痉挛性瘫痪 周围神经病 感染性 周围神经损害 淋巴细胞白血病 电生理检查 炎性浸润 腓神经 

分 类 号：R744[医药卫生—神经病学与精神病学]