急性前庭神经炎时前庭和视觉皮质的代谢变化  

Metabolic changes in vestibular and visual cortices in acute vestibular neuritis

作　　者：Bense S. Bartenstein P. Lochmann M. 郭俊 

机构地区：[1]Department of Neurology, Johannes Gutenberg- University, Langenbeckstrasse 1, D- 55101 Mainz, Germany Dr

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第4期9-9,共1页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Five right- handed patients with a right- sided vestibular neuritis were examined twice with fluorodeoxyglucose positron emission tomography while lying supine with eyes closed: once during the acute stage (mean, 6.6 days) and then 3 months later when central vestibular compensation had occurred. Regional cerebral glucose metabolism (rCGM) was significantly increased (p < 0.001 uncorrected) during the acute stage in multisensory vestibular cortical and subcortical areas (parietoinsular vestibular cortex in the posterior insula, posterolateral thalamus, anterior cingulate gyrus [Brodmann area 32/24], pontomesencephalic brainstem, hippocampus). Simultaneously, there was a significant rCGM decrease in the visual (Brodmann area 17 to 19) and somatosensory cortex areas in the postcentral gyrus as well as in parts of the auditory cortex (transverse temporal gyrus). Fluorodeoxyglucose positron emission tomography thus allows imaging of the cortical activation pattern that is induced by unilateral peripheral vestibular loss. It was possible to demonstrate that the central vestibular system including the vestibular cortex exhibits a visual- vestibular activation- deactivation pattern during the acute stage of vestibular neuritis similar to that in healthy volunteers during unilaterl labyrinthine stimulation. Contrary to experimental vestibular stimulation, the activation of the vestibular cortex was not bilateral but was unilateral and contralateral to the right- sided labyrinthine failure.Five right- handed patients with a right- sided vestibular neuritis were examined twice with fluorodeoxyglucose positron emission tomography while lying supine with eyes closed: once during the acute stage (mean, 6.6 days) and then 3 months later when central vestibular compensation had occurred. Regional cerebral glucose metabolism (rCGM) was significantly increased (p < 0.001 uncorrected) during the acute stage in multisensory vestibular cortical and subcortical areas (parietoinsular vestibular cortex in the posterior insula, posterolateral thalamus, anterior cingulate gyrus [Brodmann area 32/24], pontomesencephalic brainstem, hippocampus). Simultaneously, there was a significant rCGM decrease in the visual (Brodmann area 17 to 19) and somatosensory cortex areas in the postcentral gyrus as well as in parts of the auditory cortex (transverse temporal gyrus). Fluorodeoxyglucose positron emission tomography thus allows imaging of the cortical activation pattern that is induced by unilateral peripheral vestibular loss. It was possible to demonstrate that the central vestibular system including the vestibular cortex exhibits a visual- vestibular activation- deactivation pattern during the acute stage of vestibular neuritis similar to that in healthy volunteers during unilaterl labyrinthine stimulation. Contrary to experimental vestibular stimulation, the activation of the vestibular cortex was not bilateral but was unilateral and contralateral to the right- sided labyrinthine failure.

关 键 词：前庭功能 前庭神经炎 视觉皮质 代谢变化 听觉皮层 前庭中枢 中央后回 单侧性 颞横回 右利手 

分 类 号：R745[医药卫生—神经病学与精神病学]