周期性联合体对Creutzfeldt-Jakob病的诊断价值  

Diagnostic value of periodic complexes in Cre-utzfeldt-Jakob disease

作　　者：Steinhoff B.J. Zerr I. Glatting M. 黄卫东 

机构地区：[1]Steinhoff, Epilepsy Center Kork, Landstrasse 1, 77694 Kehl- Kork,Germany Dr

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第4期11-11,共1页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：In 1996, our group published objective electroencephalogram (EEC) criteria to define periodic sharp- wave complexes (PSWCs) suggestive for Creutzfeldt- Jakob disease (CJD). These criteria have since then been strictly applied in all cases reported to us as possible CJD in the course of the German CJD surveillance study. Furthermore, EEG analysis of the records was performed without any additional information on complementary clinical and laboratory data. In this study, we investigated sensitivity, specificity, and the predictive values of these EEG criteria exclusively in cases in which autopsy confirmed (n = 150) or excluded (n = 56) CJD. EEG criteria were positive in 64% (n = 96) of the CJD cases and falsely positive in 9% (n = 5) of other dementias. The resulting figures for sensitivity, specificity, and positive and negative predictive values were 64% , 91% , 95% , and 49% , respectively. In the falsely positive cases, Alzheimer’ s disease (n = 4) and vascular dementia (n = 1) were the underlying diseases. However, only in one of these five cases both clinical and EEG data would have led to the false- positive result to diagnose probable CJD. These data prove the high diagnostic value of our objective EEG criteria in CJD.In 1996, our group published objective electroencephalogram (EEC) criteria to define periodic sharp- wave complexes (PSWCs) suggestive for Creutzfeldt- Jakob disease (CJD). These criteria have since then been strictly applied in all cases reported to us as possible CJD in the course of the German CJD surveillance study. Furthermore, EEG analysis of the records was performed without any additional information on complementary clinical and laboratory data. In this study, we investigated sensitivity, specificity, and the predictive values of these EEG criteria exclusively in cases in which autopsy confirmed (n = 150) or excluded (n = 56) CJD. EEG criteria were positive in 64% (n = 96) of the CJD cases and falsely positive in 9% (n = 5) of other dementias. The resulting figures for sensitivity, specificity, and positive and negative predictive values were 64% , 91% , 95% , and 49% , respectively. In the falsely positive cases, Alzheimer’ s disease (n = 4) and vascular dementia (n = 1) were the underlying diseases. However, only in one of these five cases both clinical and EEG data would have led to the false- positive result to diagnose probable CJD. These data prove the high diagnostic value of our objective EEG criteria in CJD.

关 键 词：诊断标准 假阳性 阴性预测值 疑似患者 阳性病例 血管性痴呆 潜在疾病 尖波 特异性 他型 

分 类 号：R742.89[医药卫生—神经病学与精神病学]