肌张力障碍DYT1突变非显性携带者纹状体D_2受体结合位点减少  

Decreased striatal D_2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation

作　　者：Asanuma K. Okulski J. D. Eidelberg 姚庆和 

机构地区：[1]Center for Neurosciences, N. Shore- Long Isl. Jewish Res. Inst., 350 Community Drive, Manhasset, NY 11030, United States Dr.

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第6期46-46,共1页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：To determine whether reduced striatal D2 receptor binding reported in patients with idiopathic torsion dystonia is associated with the genotype, the authors used PET and [11C]- raclopride to assess non- manifesting carriers of the DYT1 mutation. D2 receptor binding was reduced by approximately 15% in caudate and putamen (p < 0.005). These results suggest that striatal D2 binding reductions are a trait feature of the DYT1 genotype.To determine whether reduced striatal D2 receptor binding reported in patients with idiopathic torsion dystonia is associated with the genotype, the authors used PET and [11C]- raclopride to assess non- manifesting carriers of the DYT1 mutation. D2 receptor binding was reduced by approximately 15% in caudate and putamen (p < 0.005). These results suggest that striatal D2 binding reductions are a trait feature of the DYT1 genotype.

关 键 词：肌张力障碍 DYT1 D₂ 受体结合位点 携带者 纹状体 壳核 尾状核 

分 类 号：R746[医药卫生—神经病学与精神病学]