动力敏感性对比磁共振成像对缺血性卒中患者异常脑血流量的检测  

Abnormal intravoxel cerebral blood flow heterogeneity in human ischemic stroke determined by dynamic susceptibility contrast magnetic resonance imaging

作　　者：PerkiJ. Soinne L. φstergaard L. 雷翀 

机构地区：[1]Department of Child Neurology, Hosp. for Children and Adolescents, Helsinki University Central Hospital, Lastenlinnantie 2, FIN- 00290 Helsinki, Finland

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第6期50-51,共2页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Background and Purpose - The determination of cerebral blood flow heterogeneity (FH) by dynamic susceptibility contrast (DSC) magnetic resonance imaging has recently been proposed as a tool to predict final infarct size in acute stroke. In this study, we describe the evolution of FH during the first week as well as its correlation to the patients’ clinical status. Methods - Ten patients with ischemic stroke were studied with DSC MRI and diffusion- weighted imaging in hyperacute ( < 6 hours) phase, at 24 hours, and 1 week after symptom onset. In addition to intravoxel FH, cerebral blood volume (CBV), cerebral blood flow (CBF), and contrast agent mean transit time (MTT)- were determined from DSC MRI. All patients were evaluated neurologically with National Institute of Health Stroke Scale concurrently with the imaging sessions. Results - All patients showed infarct growth, judged by diffusion- weighted imaging, during the week with simultaneous decrease in the sizes of FH, CBV, CBF, and MTT abnormalities. The FH abnormality was shown to be larger than CBV and CBF abnormalities at the hyperacute phase and 24 hours, but smaller than MTT abnormality in all 3 imaging sessions. The sizes of hyperacute FH, CBV, CBF, and MTT abnormalities correlated well with infarct size at 24 hours and at 1 week. Additionally, FH was the only perfusion parameter that correlated with the clinical score. Conclusions - FH predicts infarct size equally well with the other perfusion parameters but is superior in correlation with the clinical score. FH can easily be incorporated to hyperacute stroke imaging without additional efforts.Background and Purpose - The determination of cerebral blood flow heterogeneity (FH) by dynamic susceptibility contrast (DSC) magnetic resonance imaging has recently been proposed as a tool to predict final infarct size in acute stroke. In this study, we describe the evolution of FH during the first week as well as its correlation to the patients’ clinical status. Methods - Ten patients with ischemic stroke were studied with DSC MRI and diffusion- weighted imaging in hyperacute ( < 6 hours) phase, at 24 hours, and 1 week after symptom onset. In addition to intravoxel FH, cerebral blood volume (CBV), cerebral blood flow (CBF), and contrast agent mean transit time (MTT)- were determined from DSC MRI. All patients were evaluated neurologically with National Institute of Health Stroke Scale concurrently with the imaging sessions. Results - All patients showed infarct growth, judged by diffusion- weighted imaging, during the week with simultaneous decrease in the sizes of FH, CBV, CBF, and MTT abnormalities. The FH abnormality was shown to be larger than CBV and CBF abnormalities at the hyperacute phase and 24 hours, but smaller than MTT abnormality in all 3 imaging sessions. The sizes of hyperacute FH, CBV, CBF, and MTT abnormalities correlated well with infarct size at 24 hours and at 1 week. Additionally, FH was the only perfusion parameter that correlated with the clinical score. Conclusions - FH predicts infarct size equally well with the other perfusion parameters but is superior in correlation with the clinical score. FH can easily be incorporated to hyperacute stroke imaging without additional efforts.

关 键 词：缺血性卒中 脑血流量 超急性期 梗死体积 磁共振血流成像 急性卒中 磁共振成像 弥散加权成像 脑梗死容积 影像学检查 

分 类 号：R743.3[医药卫生—神经病学与精神病学]