临床前阿尔茨海默病在发病前1.5～8年的神经心理测试表现  

Preclinical Alzheimer disease: Neuropsychological test performance 1.5 to 8 years prior to onset

作　　者：Saxton J. Lopez O.L. Ratcliff G. 方伯言 

机构地区：[1]University of Pittsburg h, Oxford Building, Pittsburgh, PA15213, United States Dr.

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第7期36-37,共2页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Objective: To determine if individuals ultimately diagnosed with Alzheimer dis ease (AD) exhibited evidence of cognitive impairment on neuropsychological tests administered between1.5 years and 8.1 years before dementia onset. Methods: A t otal of 693 community-dwelling individuals, part of the Cardiovascular Health S tudy, completed a neuropsychological test battery in 1991/92. Subjects were foll owed annually over the next 8 years (median follow-up = 7.4 years). Seventy-tw o individuals were ultimately diagnosed with AD (median follow-up = 4.5 years): 24 with AD onset 1.5 to 3.4 years after baseline neuropsychological testing, 20 with AD onset 3.5 to 5.0 years after testing, and 28 with onset 5.1 to 8.1 year s after testing. A total of 621 individuals remained nondemented throughout the 8 years of follow-up (median follow-up = 7.5 years). Results: Subjects ultimat ely diagnosed with AD had poorer scores on baseline neuropsychological measures than subjects who remained nondemented. Although individuals closest to AD onset (i.e., 1.5 to 3.4 years) performed the most poorly, cognitive impairment was de tected in individuals who did not develop AD until 5 to 8 years later. Conclusio ns: Cognitive changes can be detected well before onset of Alzheimer disease.Objective: To determine if individuals ultimately diagnosed with Alzheimer dis ease (AD) exhibited evidence of cognitive impairment on neuropsychological tests administered between1.5 years and 8.1 years before dementia onset. Methods: A t otal of 693 community-dwelling individuals, part of the Cardiovascular Health S tudy, completed a neuropsychological test battery in 1991/92. Subjects were foll owed annually over the next 8 years (median follow-up = 7.4 years). Seventy-tw o individuals were ultimately diagnosed with AD (median follow-up = 4.5 years): 24 with AD onset 1.5 to 3.4 years after baseline neuropsychological testing, 20 with AD onset 3.5 to 5.0 years after testing, and 28 with onset 5.1 to 8.1 year s after testing. A total of 621 individuals remained nondemented throughout the 8 years of follow-up (median follow-up = 7.5 years). Results: Subjects ultimat ely diagnosed with AD had poorer scores on baseline neuropsychological measures than subjects who remained nondemented. Although individuals closest to AD onset (i.e., 1.5 to 3.4 years) performed the most poorly, cognitive impairment was de tected in individuals who did not develop AD until 5 to 8 years later. Conclusio ns: Cognitive changes can be detected well before onset of Alzheimer disease.

关 键 词：神经心理测试 阿尔茨海默病 临床前 认知功能损害 impairment 中位随访期 心血管健康 MEDIAN poorly 基线水平 

分 类 号：R749.1[医药卫生—神经病学与精神病学]