吸烟与不吸烟帕金森病患者发病年龄和运动并发症的对比研究  

Comparison of age of onset and development of motor complications between smokers and non-smokers in Parkinson's disease

作　　者：De Reuck J. De Weweire M. VanMaele G. Santens P. 张玉龙 

机构地区：[1]Department of Neurology, University Hospital, DePintelaan 185, B-9000 Ghent, Belgium

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第8期46-47,共2页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Background: There is growing evidence from case-control and from cohort studi es that smoking is inversely related to the risk of developing Parkinson’s dise ase (PD). However, it is still controversial if PD starts at an older age in eve r-smoking patients compared to never-smoking ones. Patients and methods: The p resent retrospective study compares in a large series of 512 outpatients,collect ed over the last 24 years, the age of onset of the complaints, the age at which PD was diagnosed and the start of levodopa treatment between ever-and never-sm okers. Also, the occurrence of long-term side-effects of the drug was evaluate d.184 PD patients with a history of smoking were compared with 328 who had never smoked. The subgroups with and without a family history of PD were analysed sep arately. Results: In the overall ever-smoking group, as well as in the subgroup without a family history, the onset of the disease and the time of the diagnosi s of PD and the time at which levodopa was started occurred at an older age than in the never-smoking group. This difference could not be demonstrated in the p atients with a family history, due to the low number of cases and the lack of st atistical power. Although the follow-up period was the same in both study group s, motor fluctuations and dyskinesia were more frequent and appeared earlier aft er levodopa treatment in the non-smoki- ng compared to the ever-smoking PD patients.Only for cognitive impairment the re was a non-significant trend in the smoking group. Conclusion: The present st udy confirms the protective action of smoking on PD and also suggests some modul ating effect of smoking on the dopaminergic system.Background: There is growing evidence from case-control and from cohort studi es that smoking is inversely related to the risk of developing Parkinson's dise ase (PD). However, it is still controversial if PD starts at an older age in eve r-smoking patients compared to never-smoking ones. Patients and methods: The p resent retrospective study compares in a large series of 512 outpatients,collect ed over the last 24 years, the age of onset of the complaints, the age at which PD was diagnosed and the start of levodopa treatment between ever-and never-sm okers. Also, the occurrence of long-term side-effects of the drug was evaluate d.184 PD patients with a history of smoking were compared with 328 who had never smoked. The subgroups with and without a family history of PD were analysed sep arately. Results: In the overall ever-smoking group, as well as in the subgroup without a family history, the onset of the disease and the time of the diagnosi s of PD and the time at which levodopa was started occurred at an older age than in the never-smoking group. This difference could not be demonstrated in the p atients with a family history, due to the low number of cases and the lack of st atistical power. Although the follow-up period was the same in both study group s, motor fluctuations and dyskinesia were more frequent and appeared earlier aft er levodopa treatment in the non-smoki- ng compared to the ever-smoking PD patients.Only for cognitive impairment the re was a non-significant trend in the smoking group. Conclusion: The present st udy confirms the protective action of smoking on PD and also suggests some modul ating effect of smoking on the dopaminergic system.

关 键 词：帕金森病 发病年龄 左旋多巴 多巴胺能系统 治疗开始时间 吸烟患者 副作用发生率 队列研究 发病风险 亚组 

分 类 号：R742.5[医药卫生—神经病学与精神病学]