帕金森病早期[^(99m)Tc]TRODAT-1SPECT成像分析与嗅觉鉴定相关  

[^(99m)Tc]TRODAT-1 SPECT imaging correlates with odor identification in early Parkinson disease

作　　者：Siderowf A. Newberg A. Chou K.L. 王孝文 

机构地区：[1]Parkinson Disease and Movement Disorders Center, Pennsylvania Hospital, 330 South Ninth Street, Philadelphia, PA 19107, United States,Dr.

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第9期54-55,共2页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Background: In vivo imaging of the dopamine transporter with [99mTc]TRODAT-1 (TRODAT) and olfactory testing have both been proposed as potential biomarkers in Parkinson disease (PD). Objective: To evaluate the relationship between TRODAT SPECT imaging, odor identification skills, and motor function in patients with early PD. Methods: Twenty-four patients with a clinical diagnosis of early-stage PD (mean Hoehn &Yahr stage=1.4) underwent TRODAT imaging, Unified PD Rating Scale (UPDRS) ratings of motor function, and administration of the University of Pennsylvania Smell Identification Test (UPSIT). Brain images were obtained using a standardized processing protocol and specific uptake ratios for striatal regions of interest were calculated. Partial correlations between the imaging indices,disease duration, UPSIT scores,and UPDRS motor scores were then calculated. Results: UPSIT scores were correlated with TRODAT uptake in the striatum as a whole (r=0.66, p=0.001). The putamen showed the strongest correlation with the UPSIT (r=0.74; p < 0.001). The correlation between dopamine transporter density in the caudate a nd UPSIT was moderate (r=0.36, p=0.11), but was not significant. Conclusions: Ol factory function is highly correlated with dopamine transporter imaging abnormal ities in early Parkinson disease(PD).Further studies are warranted to determine whether changes over time in these two measures are also correlated in early PD.Background: In vivo imaging of the dopamine transporter with [99mTc]TRODAT-1 (TRODAT) and olfactory testing have both been proposed as potential biomarkers in Parkinson disease (PD). Objective: To evaluate the relationship between TRODAT SPECT imaging, odor identification skills, and motor function in patients with early PD. Methods: Twenty-four patients with a clinical diagnosis of early-stage PD (mean Hoehn &Yahr stage=1.4) underwent TRODAT imaging, Unified PD Rating Scale (UPDRS) ratings of motor function, and administration of the University of Pennsylvania Smell Identification Test (UPSIT). Brain images were obtained using a standardized processing protocol and specific uptake ratios for striatal regions of interest were calculated. Partial correlations between the imaging indices,disease duration, UPSIT scores,and UPDRS motor scores were then calculated. Results: UPSIT scores were correlated with TRODAT uptake in the striatum as a whole (r=0.66, p=0.001). The putamen showed the strongest correlation with the UPSIT (r=0.74; p < 0.001). The correlation between dopamine transporter density in the caudate a nd UPSIT was moderate (r=0.36, p=0.11), but was not significant. Conclusions: Ol factory function is highly correlated with dopamine transporter imaging abnormal ities in early Parkinson disease(PD).Further studies are warranted to determine whether changes over time in these two measures are also correlated in early PD.

关 键 词：帕金森病 成像分析 嗅觉功能 纹状体区 多巴 壳核 转运体 摄取率 运动评分 嗅觉试验 

分 类 号：R742.5[医药卫生—神经病学与精神病学]