精神疾病在偏头痛向过量服用止痛药所致头痛进展中的作用  

Psychiatric comorbidity in the evolution from migraine to medication overuse headache

作　　者：Radat F. Creac’ h C. Swendsen J.D. 高宗恩 

机构地区：[1]CHU Pellegrin, 3307 6 Bordeaux Cedex, France Dr.

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第10期7-8,共2页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：We set out to study the role of psychiatric comorbidity in the evolution of m igraine to medication overuse headache (MOH)- by a comparative study of 41 migr aineurs (MIG) and 41 patients suffering from MOH deriving from migraine. There w as an excess risk of suffering from mood disorders [odds ratio (OR)=4.5, 95% c onfidence interval (CI) 1.5, 13.5], anxiety (OR=5, 95% CI 1.2, 10.7) and disor ders associated with the use of psychoactive substances other than analgesics (O R=7.6, 95% CI 2.2, 26.0) in MOH compared with MIG. Retrospective study of the order of occurrence of disorders showed that in the MOH group, psychiatric disor ders occurred significantly more often before the transformation from migraine i nto MOH than after. There was no crossed- family transmission between MOH and p sychiatric disorders, except for substance- related disorders. MOH patients hav e a greater risk of suffering from anxiety and depression, and these disorders m ay be a risk factor for the evolution of migraine into MOH. Moreover, MOH patien ts have a greater risk of suffering from substance- related disorders than MIG sufferers. This could be due to the fact that MOH is part of the spectrum of add ictive disorders.We set out to study the role of psychiatric comorbidity in the evolution of m igraine to medication overuse headache (MOH)- by a comparative study of 41 migr aineurs (MIG) and 41 patients suffering from MOH deriving from migraine. There w as an excess risk of suffering from mood disorders [odds ratio (OR)=4.5, 95% c onfidence interval (CI) 1.5, 13.5], anxiety (OR=5, 95% CI 1.2, 10.7) and disor ders associated with the use of psychoactive substances other than analgesics (O R=7.6, 95% CI 2.2, 26.0) in MOH compared with MIG. Retrospective study of the order of occurrence of disorders showed that in the MOH group, psychiatric disor ders occurred significantly more often before the transformation from migraine i nto MOH than after. There was no crossed- family transmission between MOH and p sychiatric disorders, except for substance- related disorders. MOH patients hav e a greater risk of suffering from anxiety and depression, and these disorders m ay be a risk factor for the evolution of migraine into MOH. Moreover, MOH patien ts have a greater risk of suffering from substance- related disorders than MIG sufferers. This could be due to the fact that MOH is part of the spectrum of add ictive disorders.

关 键 词：精神疾病 情绪障碍 精神活性物质 成瘾性疾病 

分 类 号：R747.2[医药卫生—神经病学与精神病学]