偏头痛对癫痫的影响:一项前瞻性的预后研究  

The impact of migraine on epilepsy: A prospective prognosis study

作　　者：Velio■lu S.K. Boz C. zmeno■lu M. 王孝文 

机构地区：[1]Neurology Department, M edical Faculty, Karadeniz Technical University (KTU), Trabzon, Turkey

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第10期8-9,共2页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：The effect of migraine on the prognosis of epilepsy has not been reported. Th e aim of this prospective 5- 10- year follow- up study was to examine some ou tcome measures and the cumulative probability of being seizure- free in epileps y patients with migraine, and to compare their results with those of epilepsy pa tients without migraine. Fifty- nine patients (40 women; mean age 25 years) wer e diagnosed with both epilepsy and migraine (EM group). The control group consis ted of 56 patients with epilepsy but without migraine (E group). Both groups were recruited and followed up over similar periods. W e compared the outcome variables in the EM group with those in the E group. Kapl an- Meier methods were used to assess the seizurefree curves. The EM group had a significantly lower cumulative probability of being seizure- free over 10 yea rs compared with the E group. The other epilepsy outcome measures at follow- up differed significantly between the groups, with the EM group having a longer du ration of epilepsy, a lower early treatment response, and a higher incidence of intractable epilepsy and achieving remission with polytherapy, and more seizure control and medication problems for at least the last 2 years of followup. Comor bid migraine had a negative effect on the prognosis of epilepsy.The effect of migraine on the prognosis of epilepsy has not been reported. Th e aim of this prospective 5- 10- year follow- up study was to examine some ou tcome measures and the cumulative probability of being seizure- free in epileps y patients with migraine, and to compare their results with those of epilepsy pa tients without migraine. Fifty- nine patients (40 women; mean age 25 years) wer e diagnosed with both epilepsy and migraine (EM group). The control group consis ted of 56 patients with epilepsy but without migraine (E group). Both groups were recruited and followed up over similar periods. W e compared the outcome variables in the EM group with those in the E group. Kapl an- Meier methods were used to assess the seizurefree curves. The EM group had a significantly lower cumulative probability of being seizure- free over 10 yea rs compared with the E group. The other epilepsy outcome measures at follow- up differed significantly between the groups, with the EM group having a longer du ration of epilepsy, a lower early treatment response, and a higher incidence of intractable epilepsy and achieving remission with polytherapy, and more seizure control and medication problems for at least the last 2 years of followup. Comor bid migraine had a negative effect on the prognosis of epilepsy.

关 键 词：预后研究 随访研究 预后指标 难治性癫痫 多药治疗 本项 

分 类 号：R747.2[医药卫生—神经病学与精神病学]