苍白球刺激可缓解肌阵挛-肌张力障碍综合征  

Pallidal stimulation relieves myoclonus-dys-tonia syndrome

作　　者：Magarios-Ascone C.M. Regidor I. Martnez-Castr-illo J.C. 邓剑平 

机构地区：[1]Neurologa Experimental, Dipartimento di Investigación, Hospital Ramón Y Cajal, Madrid 28034, Spain Dr.

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第10期29-30,共2页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：A patient with myoclonus- dystonia syndrome was treated by implanting electr odes in the internal segment of the globus pallidus (GPi) and applying deep brai n stimulation. Surgery was done in two sessions. The most affected limb was trea ted first and the other limb one year later. Neuronal recordings showed that mos t pallidal neurones discharged in bursts at a relatively low firing rate (mean ( SD), 46 (18) Hz) compared with cells in the GPi in patients with Parkinson’ s d isease. Neurones modified the rate and mode of discharge with dystonic postures and rapid involuntary contractions of limb muscles. Neurological examination at 24 months after surgery showed a decline of 47.8% and 78.5% in the Burke- F ahn- Marsden and disability rating scales, respectively.A patient with myoclonus- dystonia syndrome was treated by implanting electr odes in the internal segment of the globus pallidus (GPi) and applying deep brai n stimulation. Surgery was done in two sessions. The most affected limb was trea ted first and the other limb one year later. Neuronal recordings showed that mos t pallidal neurones discharged in bursts at a relatively low firing rate (mean ( SD), 46 (18) Hz) compared with cells in the GPi in patients with Parkinson’ s d isease. Neurones modified the rate and mode of discharge with dystonic postures and rapid involuntary contractions of limb muscles. Neurological examination at 24 months after surgery showed a decline of 47.8% and 78.5% in the Burke- F ahn- Marsden and disability rating scales, respectively.

关 键 词：苍白球 肌阵挛 爆发式放电 帕金森病 神经元放电 深部脑刺激 内侧部 植入电极 放电频率 张力障碍 

分 类 号：R741[医药卫生—神经病学与精神病学]