Tourette综合征和深部脑刺激  

Tourette’s syndrome and deep brain stimulation

作　　者：Houeto J.L. Karachi C. Mallet L. Y. Agid 邓剑平 

机构地区：[1]Centre d’Investigation Clinique, Hpital de la Sal pêtrière, 47 boulevard de l’ Hpital, 750 13 Paris, France Dr.

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第10期30-30,共1页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：In this prospective double blind randomised “ N of 1” study, a patient wit h a severe form of Tourette’ s syndrome was treated with bilateral high frequen cy stimulation of the centromedianparafascicular complex (Ce- Pf) of the thalam us, the internal part of the globus pallidus (GPi), or both. Stimulation of eith er target improved tic severity by 70% , markedly ameliorated coprolalia, and e liminated self injuries. Severe forms of Tourette’ s syndrome may benefit from stimulation of neuronal circuits within the basal ganglia, thus confirming the r ole of the dysfunction of limbic striatopallido- thalamo- cort- ical systems in this disorder.In this prospective double blind randomised “ N of 1” study, a patient wit h a severe form of Tourette’ s syndrome was treated with bilateral high frequen cy stimulation of the centromedianparafascicular complex (Ce- Pf) of the thalam us, the internal part of the globus pallidus (GPi), or both. Stimulation of eith er target improved tic severity by 70% , markedly ameliorated coprolalia, and e liminated self injuries. Severe forms of Tourette’ s syndrome may benefit from stimulation of neuronal circuits within the basal ganglia, thus confirming the r ole of the dysfunction of limbic striatopallido- thalamo- cort- ical systems in this disorder.

关 键 词：深部脑刺激 TOURETTE综合征 苍白球 秽语症 内侧部 纹状体 严重型 电刺激 肌张力 边缘系统 

分 类 号：R749.94[医药卫生—神经病学与精神病学]