环孢素成功治疗顽固性慢性炎症性脱髓鞘性多发性神经病  

Intractable chronic inflammatory demyelinating polyneuropathy treated successfully with ciclosporin

作　　者：Odaka M. Tatsumoto M. Susuki K. 史焕昌 

机构地区：[1]Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293, Japan

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第11期38-39,共2页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Background: Chronic inflammatory demyelinating polyneu-ropathy (CIDP) is a heterogeneous disorder and both clinical course and response to treatment vary widely. Because of the propensity for relapse, CIDP requires maintenance therapy after the initial response to treatment. There is no consensus regarding this in the published literature. Present report: A patient with CIDP was treated with oral prednisolone and cyclophosphamide pulse therapy but required repeated plasma exchange and intravenous immunoglobulin (IVIg). Treatment with ciclosporin freed the patient from repeated IVIg administration. Therapeutic responses in 14 subsequent cases including three patients who showed improvement with ciclosporin are also presented along with an algorithm of the authors’suggested protocol for treatment. Conclusion: Ciclosporin should be considered for patients with intractable CIDP who require repeated IVIg.Background: Chronic inflammatory demyelinating polyneu-ropathy (CIDP) is a heterogeneous disorder and both clinical course and response to treatment vary widely. Because of the propensity for relapse, CIDP requires maintenance therapy after the initial response to treatment. There is no consensus regarding this in the published literature. Present report: A patient with CIDP was treated with oral prednisolone and cyclophosphamide pulse therapy but required repeated plasma exchange and intravenous immunoglobulin (IVIg). Treatment with ciclosporin freed the patient from repeated IVIg administration. Therapeutic responses in 14 subsequent cases including three patients who showed improvement with ciclosporin are also presented along with an algorithm of the authors’suggested protocol for treatment. Conclusion: Ciclosporin should be considered for patients with intractable CIDP who require repeated IVIg.

关 键 词：环孢素 反应差异 临床病程 血浆置换 强的松龙 异质性疾病 

分 类 号：R744[医药卫生—神经病学与精神病学]