一氧化氮水平与体外受精过程中胚胎发育异常和妊娠结局的关系  

0045. Nitric oxide is associated with poor embryo quality and pregnancy outcome in in vitro fertilization cycles

作　　者：Lee T.-H. 闫坤 

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2005年第1期30-30,共1页Core Journal in Obstetrics/Gynecology

摘　　要：Objective To evaluate the association between follicular and serum ni tric oxid e (NO) levels and embryo development and outcome in IVF.Design Prospective,case -control study. Setting University hospital, tertiary medical center. Patient(s ) Eighteen patients with tubal or peritoneal factor infertility and 18 female pa rtners from couples with male factor infertility underwent controlled ovarian st imulation and IVF/intracytoplasmic sperm injection (ICSI). Intervention(s) Contr olled ovarian stimulation and oocyte retrieval followed by IVF/ICSI and embryo c ulture. Main outcome measure(s) Degree of fragmentation of embryos and pregnancy rate. Result(s) Higher follicular NO levels were associated with advanced fragm entation of embryos. Follicular soluble Fas could not prevent embryo fragmentati on. Higher serum NO levels were found among nonpregnant patients with tubal or p eritoneal factor infertility. No elevated serum NO levels were found in the fema le partners from couples with male factor infertility. Conclusion(s) Up-regulat ion of serum NO is associated with implantation failure in patients with tubal o r peritoneal factor infertility.Objective To evaluate the association between follicular and serum ni tric oxid e (NO) levels and embryo development and outcome in IVF.Design Prospective,case -control study. Setting University hospital, tertiary medical center. Patient(s ) Eighteen patients with tubal or peritoneal factor infertility and 18 female pa rtners from couples with male factor infertility underwent controlled ovarian st imulation and IVF/intracytoplasmic sperm injection (ICSI). Intervention(s) Contr olled ovarian stimulation and oocyte retrieval followed by IVF/ICSI and embryo c ulture. Main outcome measure(s) Degree of fragmentation of embryos and pregnancy rate. Result(s) Higher follicular NO levels were associated with advanced fragm entation of embryos. Follicular soluble Fas could not prevent embryo fragmentati on. Higher serum NO levels were found among nonpregnant patients with tubal or p eritoneal factor infertility. No elevated serum NO levels were found in the fema le partners from couples with male factor infertility. Conclusion(s) Up-regulat ion of serum NO is associated with implantation failure in patients with tubal o r peritoneal factor infertility.

关 键 词：体外受精 妊娠结局 一氧化氮水平 胚胎培养 发育异常 诱发排卵 卵母细胞 男方因素 显微注射 第三医学 

分 类 号：R711.6[医药卫生—妇产科学]