它莫西芬治疗乳腺癌后继发恶性混合性中胚层肿瘤  

Malignant mixed mesodermal tu mor after tamoxifen therapy for breast cancer

作　　者：Hubalek M. Ramoni A. Mueller-Holz ner E. Marth C. 郭慧芳 

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2005年第2期57-57,共1页Core Journal in Obstetrics/Gynecology

摘　　要：The risk of tamoxifen related endome trial neoplasm has been confirmed by multiple studies.Especially rare en-dometrial tumors seem to develop more frequently under tamoxifen therapy.A recent analysis showed a substantially higher risk for malignant mixed meso dermal tumor(MMMT;designated in the WHO classification of female genital tract neoplasms as carcinosarcoma )in association with tamoxifen intake.We are reporting a case of a 40-year -old multiparous premenopausa l woman who received tamoxifen 20mg daily for 2years afte r the surgical treat-ment of breast cancer and subsequent adjuvant chemother-apy.Two years after initiation of ta moxifen treatment,the patient developed anMMMTof the uterus.More than 64months after radical hysterectomy,salpingo -oophorecto-my,and pelvic lymphadenectomy,she remains recur-rence -free for MMMT.Unfortunately,she developed a local recurrence of her breast cancer in 2003.After surgi-cal treatment,she is currently bein g treated with anastro-zole.We are reporting a rare case of a premenopausal pa-tient who developed a MMMT within short time of tamoxifen exposure for stage I breast cancer.The risk of tamoxifen related endome trial neoplasm has been confirmed by multiple studies.Especially rare en-dometrial tumors seem to develop more frequently under tamoxifen therapy.A recent analysis showed a substantially higher risk for malignant mixed meso dermal tumor(MMMT;designated in the WHO classification of female genital tract neoplasms as carcinosarcoma )in association with tamoxifen intake.We are reporting a case of a 40-year -old multiparous premenopausa l woman who received tamoxifen 20mg daily for 2years afte r the surgical treat-ment of breast cancer and subsequent adjuvant chemother-apy.Two years after initiation of ta moxifen treatment,the patient developed anMMMTof the uterus.More than 64months after radical hysterectomy,salpingo -oophorecto-my,and pelvic lymphadenectomy,she remains recur-rence -free for MMMT.Unfortunately,she developed a local recurrence of her breast cancer in 2003.After surgi-cal treatment,she is currently bein g treated with anastro-zole.We are reporting a rare case of a premenopausal pa-tient who developed a MMMT within short time of tamoxifen exposure for stage I breast cancer.

关 键 词：它莫西芬 乳腺癌手术 混合性 中胚层 癌局部复发 辅助化疗 阿纳托唑 子宫内膜 罕见病例 绝经前期 

分 类 号：R737.9[医药卫生—肿瘤]