绝经后联合激素治疗中孕激素用量与子宫内膜癌患病风险  

Dose of progestin in postmenopausal-com-bined hormone therapy and risk of endometrial cancer

作　　者：Reed S.D. Voigt L.F. Beresford S.A.A. 程广艳 

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2005年第3期12-13,共2页Core Journal in Obstetrics/Gynecology

摘　　要：We studied the impact of progestin dose on this risk. The pattern and number of days per month that progestin is given in postmenopausal combined hormone therapy appears to affect endometrial cancer risk. We assessed the impact of progestin dose on this risk. A population based, case control study included 647 cases with endometrial cancer and 1209 controls. Among users of estrogen with medroxyprogesterone acetate (MPA) 10 to 24 days/month, women who took >100 mg/month had an endometrial cancer risk that was equal to that of hormone nonusers (95% CI 0.6- 1.7). The corresponding relative risk was 0.8 (95% CI 0.5- 1.5) in those who used a lower monthly MPA dose for 10 to 24 days/month. Among users of a continuous combined hormone regimen, the risk of endometrial cancer was low relative to hormone nonusers, regardless of MPA dose. Among the combined hormone regimens most commonly used by postmenopausal women today, MPA monthly dose bears little or no relation to endometrial cancer risk.We studied the impact of progestin dose on this risk. The pattern and number of days per month that progestin is given in postmenopausal combined hormone therapy appears to affect endometrial cancer risk. We assessed the impact of progestin dose on this risk. A population based, case control study included 647 cases with endometrial cancer and 1209 controls. Among users of estrogen with medroxyprogesterone acetate (MPA) 10 to 24 days/month, women who took >100 mg/month had an endometrial cancer risk that was equal to that of hormone nonusers (95% CI 0.6- 1.7). The corresponding relative risk was 0.8 (95% CI 0.5- 1.5) in those who used a lower monthly MPA dose for 10 to 24 days/month. Among users of a continuous combined hormone regimen, the risk of endometrial cancer was low relative to hormone nonusers, regardless of MPA dose. Among the combined hormone regimens most commonly used by postmenopausal women today, MPA monthly dose bears little or no relation to endometrial cancer risk.

关 键 词：患病风险 联合激素治疗 激素用量 发病风险 激素治疗者 醋酸甲羟孕酮 病例对照研究 

分 类 号：R737.33[医药卫生—肿瘤]