复发性卵巢粒层细胞瘤的激素疗法:病例报道及文献回顾  

Hormonal treatment of a recurrent granulosa cell tumor of the ovary:Case report and review of the literature

作　　者：Hardy R.D. Bell J.G. Nicely C.J. Reid G.C. 侯巍 

机构地区：[1]C/o Research Department, Riverside Methodist Hospital, 3535 Olentangy River Road, Columbus, OH 43214, United States

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2005年第7期47-47,共1页Core Journal in Obstetrics/Gynecology

摘　　要：Background. Granulosa cell tumors of the ovary are rare, primarily treated surgically. In advanced or recurrent disease, data are inconclusive regarding the benefit of either primary or adjuvant chemotherapy. Hormonal therapy has been suggested as an alternative treatment. Case. Our patient had three recurrences of estrogen receptor negative and progesterone receptor positive GCT, the first two treated by surgery with or without adjuvant chemotherapy. For the third recurrence, the patient received alternating biweekly cycles of megestrol and tamoxifen. Computed tomography showed stable disease at 6 months, partial response at 18 months, and complete response at 22 months. The patient continues on hormonal therapy and has been disease- free for 5 years. Conclusion. This study and others suggest that hormonal therapy may provide another option for treating these relatively rare tumors.Background. Granulosa cell tumors of the ovary are rare, primarily treated surgically. In advanced or recurrent disease, data are inconclusive regarding the benefit of either primary or adjuvant chemotherapy. Hormonal therapy has been suggested as an alternative treatment. Case. Our patient had three recurrences of estrogen receptor negative and progesterone receptor positive GCT, the first two treated by surgery with or without adjuvant chemotherapy. For the third recurrence, the patient received alternating biweekly cycles of megestrol and tamoxifen. Computed tomography showed stable disease at 6 months, partial response at 18 months, and complete response at 22 months. The patient continues on hormonal therapy and has been disease- free for 5 years. Conclusion. This study and others suggest that hormonal therapy may provide another option for treating these relatively rare tumors.

关 键 词：卵巢粒层细胞瘤 激素疗法 文献回顾 雌激素受体 甲地孕酮 辅助化疗 化疗疗效 孕酮受体 无瘤存活 他莫西芬 

分 类 号：R737.31[医药卫生—肿瘤]