转化生长因子β受体I多聚丙氨酸重复多态性不会增加卵巢癌发病风险  

Transforming growth factor β receptor I po- lyalanine repeat polymorphism does not increase ovarian cancer risk

作　　者：Spillman M.A Schildkraut J.M Halabi S A. Berchuck 昌晓红 

机构地区：[1]Dept. of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University, Durham, NC 27710, United States

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2005年第10期30-31,共2页Core Journal in Obstetrics/Gynecology

摘　　要：Objectives. It has been suggested that the 6A allele of the type ITGFβ receptor (TGFβ R1) polyalanine repeat tract polymorphism may increase susceptibility to various types of cancer including ovarian cancer. Methods. The TGFβ R1 polyalanine polymorphism was genotyped in 588 ovarian cancer cases and 614 controls from a population- based case- control study in North Carolina. Results. Significant racial differences in the frequency of the 6A allele were observed between Caucasian (10.7% ) and African- American (2.4% ) controls (P < 0.001). One or two copies of the 6A allele of the TGFβ R1 polyalanine polymorphism was carried by 18% of all controls and 19% of cases, and there was no association with ovarian cancer risk (OR = 1.07, 95% CI 0.80- 1.44). The odds ratio for 6A homozygotes was 1.81 (95% CI 0.65- 5.06), but these comprised only 0.98% of controls and 1.70% of cases. Conclusions. The 6A allele of the TGFβ R1 polyalanine polymorphism does not appear to increase ovarian cancer risk. Larger studies would be needed to exclude the possibility that the small fraction of individuals who are 6A homozygotes have an increased risk of ovarian or other cancers.Objectives. It has been suggested that the 6A allele of the type ITGFβ receptor (TGFβ R1) polyalanine repeat tract polymorphism may increase susceptibility to various types of cancer including ovarian cancer. Methods. The TGFβ R1 polyalanine polymorphism was genotyped in 588 ovarian cancer cases and 614 controls from a population- based case- control study in North Carolina. Results. Significant racial differences in the frequency of the 6A allele were observed between Caucasian (10.7% ) and African- American (2.4% ) controls (P < 0.001). One or two copies of the 6A allele of the TGFβ R1 polyalanine polymorphism was carried by 18% of all controls and 19% of cases, and there was no association with ovarian cancer risk (OR = 1.07, 95% CI 0.80- 1.44). The odds ratio for 6A homozygotes was 1.81 (95% CI 0.65- 5.06), but these comprised only 0.98% of controls and 1.70% of cases. Conclusions. The 6A allele of the TGFβ R1 polyalanine polymorphism does not appear to increase ovarian cancer risk. Larger studies would be needed to exclude the possibility that the small fraction of individuals who are 6A homozygotes have an increased risk of ovarian or other cancers.

关 键 词：转化生长因子 β受体 发病风险 多态性 等位基因纯合子 高加索人 重复序列 非裔美国人 卡罗莱纳 种族差异 

分 类 号：R737.31[医药卫生—肿瘤]