紫杉醇和α-干扰素治疗1例转移性小汗腺汗孔癌  

Antitumor activity of paclitaxel and interferon-alpha in a case of metastatic eccrine porocarcinoma

作　　者：Gutermuth J. Audring H. Voit C. 崔荣 

机构地区：[1]Div.of Environ.Dermatology/Allergy, GSF Natl.Res.Ctr.Environ./Health, Technical University Munich, Neuherbergstrasse 1, D-85764Neuherberg,Germany

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2005年第1期50-51,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background.Eccrine porocarcinoma (EP) is a rare malignant tumour arising in the acrosyringium, with about 50%of the cases developing local recurrence or metastatic disease.No standard therapy protocols for metastatic disease exist.In the past, only short remissions were achieved by applying combinations of cytotoxic agents, which were associated with severe side-effects.Aim of the study.In the case reported here, the aim was to find a protocol with fewer side-effects for a patient who was not willing to undergo extensive polychemotherapy.Subject.A 67-year-old male patient with local recurrence and regional lymph node metastases after resection of EP was treated with a combination of interferon-alpha (IFN-α) 9 million units s.c.three times per week and paclitaxel 100 mg/m2 weekly i.v., which shows a side-effect profile similar to taxotere and is used in the treatment of a variety of neoplasms such as advanced squamous cell carcinoma.Main outcome.This less aggressive treatment was tolerated well and the patient responded with minor remission and long-term stable disease.Background.Eccrine porocarcinoma (EP) is a rare malignant tumour arising in the acrosyringium, with about 50%of the cases developing local recurrence or metastatic disease.No standard therapy protocols for metastatic disease exist.In the past, only short remissions were achieved by applying combinations of cytotoxic agents, which were associated with severe side-effects.Aim of the study.In the case reported here, the aim was to find a protocol with fewer side-effects for a patient who was not willing to undergo extensive polychemotherapy.Subject.A 67-year-old male patient with local recurrence and regional lymph node metastases after resection of EP was treated with a combination of interferon-alpha (IFN-α) 9 million units s.c.three times per week and paclitaxel 100 mg/m2 weekly i.v., which shows a side-effect profile similar to taxotere and is used in the treatment of a variety of neoplasms such as advanced squamous cell carcinoma.Main outcome.This less aggressive treatment was tolerated well and the patient responded with minor remission and long-term stable disease.

关 键 词：小汗腺汗孔癌 Α-干扰素 泰索帝 区域淋巴结转移 联合化疗 患者耐受性 毒副作用 鳞状细胞癌 细胞毒药物 

分 类 号：R739.5[医药卫生—肿瘤]