嗜碱性白细胞CD4^+,CD56^+血液皮肤肿瘤:新病例报道1例  

Agranular CD4+CD56+hematodermic neoplasm: A new case report (Fren)

作　　者：Chamaillard M. Beylot-Barry M. Viallard J.-F. 刘艳 

机构地区：[1]Service de Dermatologie, Hopital Haut Leveque, CHU de Bordeaux, avenue de Magellan, 33600 Pessac, France

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2005年第4期53-53,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background. "Agranular CD4+CD56+hematodermic neoplasm"are rare hematologic neoplasms which were recently shown to correspond to the plasmocytoid dendritic cells. Case report. A 83-year-old presented isolated skin lesions purple, infiltrating the dermis. The biopsy has shown a dense dermal infiltration with malignant cells CD4+CD56+CD43+. There were no bone marrow involvement and no circulating blood cells. A chemotherapy permitted a clinical remission after six courses. Unfortunately, skin and blood relapses appear four months later. After a short success of chemotherapy by DHAP, the patient died three month later. Discussion. "Agranular CD4+CD56+hematodermic neoplasm"is a distinct entity from the cutaneous primary lymphomas. Recently plasmocytoid monocyte cells have been identified as the precursor of the malignant population with the high expression of CD123, IL-3 receptor. It is a distinct clinicopathologic entity by its clinical presentation with skin tropism, bone marrow involvement with or without leukemic phase and poor prognosis independent of the kind of treatment and its particular phenotype CD4+CD56+CD43+. It would be interesting to use antibodies linked to CD123 in therapeutic because any treatment have efficacity in this disease.Background. 'Agranular CD4+CD56+hematodermic neoplasm'are rare hematologic neoplasms which were recently shown to correspond to the plasmocytoid dendritic cells. Case report. A 83-year-old presented isolated skin lesions purple, infiltrating the dermis. The biopsy has shown a dense dermal infiltration with malignant cells CD4+CD56+CD43+. There were no bone marrow involvement and no circulating blood cells. A chemotherapy permitted a clinical remission after six courses. Unfortunately, skin and blood relapses appear four months later. After a short success of chemotherapy by DHAP, the patient died three month later. Discussion. 'Agranular CD4+CD56+hematodermic neoplasm'is a distinct entity from the cutaneous primary lymphomas. Recently plasmocytoid monocyte cells have been identified as the precursor of the malignant population with the high expression of CD123, IL-3 receptor. It is a distinct clinicopathologic entity by its clinical presentation with skin tropism, bone marrow involvement with or without leukemic phase and poor prognosis independent of the kind of treatment and its particular phenotype CD4+CD56+CD43+. It would be interesting to use antibodies linked to CD123 in therapeutic because any treatment have efficacity in this disease.

关 键 词：皮肤肿瘤 CD4 CD56 新病例 嗜碱性白细胞 皮肤浸润 浆细胞样 临床缓解 恶性细胞 前体细胞 

分 类 号：R739.5[医药卫生—肿瘤]