透明细胞变异的小汗腺汗管纤维腺瘤的免疫组织化学研究  

Eccrine syringofibroadenoma of clear cell variant: An immunohistochemical study

作　　者：Bakshandeh H. KerdelF.A. P. Romanelli 罗素菊 

机构地区：[1]Dr. Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, 1444 N.W. 9th Avenue, Miami, FL 33136, United States

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2005年第8期46-47,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Eccrine syringofibroadenoma is a rare eccrine tumor first described by Mascaro in 1963. The clear cell variant was reported by Fretzin in 1995. We describe a hemorrhagic papule on the knee of a 64- year- old woman. Microscopic examination revealed epidermal- based anastomosing thin epithelial cords with ductal structures surrounded by a fibrovascular stroma. Multiple nests of glycogen- containing clear cells were also present. The tumor cells forming the epithelial cords expressed keratin. The eccrine ductal structures and clear cells additionally expressed gross cystic disease fluid protein- 15 (GCDFP- 15). Reactivity with antibodies against estrogen receptor or progesterone receptor was negative. These results favor the dual differentiation of the clear cell variant of eccrine syringofibroadenoma toward ductal and secretory portions of the eccrine sweat gland.Eccrine syringofibroadenoma is a rare eccrine tumor first described by Mascaro in 1963. The clear cell variant was reported by Fretzin in 1995. We describe a hemorrhagic papule on the knee of a 64- year- old woman. Microscopic examination revealed epidermal- based anastomosing thin epithelial cords with ductal structures surrounded by a fibrovascular stroma. Multiple nests of glycogen- containing clear cells were also present. The tumor cells forming the epithelial cords expressed keratin. The eccrine ductal structures and clear cells additionally expressed gross cystic disease fluid protein- 15 (GCDFP- 15). Reactivity with antibodies against estrogen receptor or progesterone receptor was negative. These results favor the dual differentiation of the clear cell variant of eccrine syringofibroadenoma toward ductal and secretory portions of the eccrine sweat gland.

关 键 词：小汗腺 纤维腺瘤 免疫组织化学 汗腺肿瘤 雌激素受体 汗腺导管 孕激素受体 囊肿病 角蛋白 皮索 

分 类 号：R739.5[医药卫生—肿瘤]