经常使用睫毛染料导致对苯二胺接触性变态反应  

Contact allergy to para-phenylenediamine in a permanent eyelash dye

作　　者：Teixeira M. De Wachter L. Ronsyn E. Goossens A. 张路坤 

机构地区：[1]Department of Dermatology,Katholieke Universiteit Leuven,Kapucijnenvoer 33,B-3000,Belgium Prof.

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第10期44-45,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：We present the case of a 30-year-old atopic lady with a known history of intolerance to several materials,including dark stockings,who developed a severe dermatitis on the eyelids and peri-orbital regions,as well as a conjunctivitis after having her eyelashes tinted by a beautician with a permanent black eyelash and eyebrow dye(Combinal,Dr Temt Laboratories,Austria).Patch tests revealed positive reactions to para-phenylenediamine(PPD),both diluted 0.01%and 1%in pet.,to the eyelash dye(tested semiopen as is)and to some of the azodyes tested.The permanent eyelash dye did contain PPD,the use of which is illegal but seems to be a common practice.The patient had most probably been sensitized through nylon stockings containing azo-dyes,with PPD itself cross-reacting to them.With the growth in popularity of tattooing and permanent make-up,doctors should be aware of the new uses of this old allergen.Moreover,although many manufacturers have made great efforts to improve cosmetics concerning their safety,some of them remain uninformed about cosmetic legislation or do not respect it at all.Because many of these products are acquired via internet,lack of legislation about this shopping modality is also a serious problem.We present the case of a 30-year-old atopic lady with a known history of intolerance to several materials,including dark stockings,who developed a severe dermatitis on the eyelids and peri-orbital regions,as well as a conjunctivitis after having her eyelashes tinted by a beautician with a permanent black eyelash and eyebrow dye(Combinal,Dr Temt Laboratories,Austria).Patch tests revealed positive reactions to para-phenylenediamine(PPD),both diluted 0.01%and 1%in pet.,to the eyelash dye(tested semiopen as is)and to some of the azodyes tested.The permanent eyelash dye did contain PPD,the use of which is illegal but seems to be a common practice.The patient had most probably been sensitized through nylon stockings containing azo-dyes,with PPD itself cross-reacting to them.With the growth in popularity of tattooing and permanent make-up,doctors should be aware of the new uses of this old allergen.Moreover,although many manufacturers have made great efforts to improve cosmetics concerning their safety,some of them remain uninformed about cosmetic legislation or do not respect it at all.Because many of these products are acquired via internet,lack of legislation about this shopping modality is also a serious problem.

关 键 词：接触性变态反应 对苯二胺 斑贴试验 特应性体质 眶周 开放性测试 致敏原 阳性反应 持久性 中含 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]