南亚裔加拿大移民中囊性纤维化的发生率和临床特点  

The prevalence and clinical characteristics of cystic fibrosis in South Asian Canadian immigrants

作　　者：Mei-Zahav M. Durie P. Zielenski J. M. Corey 郭战宏 

机构地区：[1]Program in Populatio n Health Sciences, Hospital for Sick Children, 555 University Avenue, Toronto, O nt. M5G 1X8, Canada Dr.

出　　处：《世界核心医学期刊文摘（儿科学分册）》2005年第10期20-21,共2页

摘　　要：Background: Cystic fibrosis (CF) is considered to be rare among individuals fr om the Indian subcontinent. Furthermore, affected individuals are reported to ex perience a more severe clinical course. Aims: It was hypothesised that CF is und er diagnosed in people of South Asian origin and therefore the prevalence may be higher than previously estimated. Methods: The prevalence of CF in the South Asian and in the general population living in the same geographic region (Metropolitan Toronto) were compared between 1996 and 20 01. Population data were obtained from the Canadian census survey. CF phenotype and genotype data were obtained from the Toronto CF database. Results: Among 381 patients with CF, 15 were of South Asian descent. The age related prevalence of CF among the South Asian and general populations was: 0-14 years, 1:9200 versu s 1:6600; 15-24 years, 1:13 200 versus 1:7600; older than 25 years, 1:56 600 ve rsus 1:12 400. Age at diagnosis, duration and severity of symptoms at diagnosis, current nutritional status, and FEV1 were similar in the two groups. While not significant, FEV1 tended to be lower (48%versus 57%predicted) among adult Sout h Asians, compared to the general CF population. Also, the percentage with pancr eatic sufficiency was higher (27%versus 16%) and the frequency of ΔF508 allel e was lower (50%versus 65.1%). Conclusions: These data suggest that the preval ence and natural history of CF in South Asians is similar to that among individu als of European origin. The relatively lower prevalence among older South Asians may reflect an improving recognition of CF in this ethnic subgroup.Background: Cystic fibrosis (CF) is considered to be rare among individuals fr om the Indian subcontinent. Furthermore, affected individuals are reported to ex perience a more severe clinical course. Aims: It was hypothesised that CF is und er diagnosed in people of South Asian origin and therefore the prevalence may be higher than previously estimated. Methods: The prevalence of CF in the South Asian and in the general population living in the same geographic region (Metropolitan Toronto) were compared between 1996 and 20 01. Population data were obtained from the Canadian census survey. CF phenotype and genotype data were obtained from the Toronto CF database. Results: Among 381 patients with CF, 15 were of South Asian descent. The age related prevalence of CF among the South Asian and general populations was: 0-14 years, 1:9200 versu s 1:6600; 15-24 years, 1:13 200 versus 1:7600; older than 25 years, 1:56 600 ve rsus 1:12 400. Age at diagnosis, duration and severity of symptoms at diagnosis, current nutritional status, and FEV1 were similar in the two groups. While not significant, FEV1 tended to be lower (48%versus 57%predicted) among adult Sout h Asians, compared to the general CF population. Also, the percentage with pancr eatic sufficiency was higher (27%versus 16%) and the frequency of ΔF508 allel e was lower (50%versus 65.1%). Conclusions: These data suggest that the preval ence and natural history of CF in South Asians is similar to that among individu als of European origin. The relatively lower prevalence among older South Asians may reflect an improving recognition of CF in this ethnic subgroup.

关 键 词：囊性纤维化 症状持续时间 自然病史 印度次大陆 临床病程 营养状况 多伦多市 表现型 胰腺功能 亚群 

分 类 号：R195[医药卫生—卫生统计学]