^(99m)Tc-MIBI显像判定化疗效果  

The pilot study of ^(99m)Tc-MIBI imaging for determinant chemotherapeutic response

作　　者：侯少洋[1] 罗泽民[1] 刘华强[1] 

机构地区：[1]广东省农垦中心医院,广东湛江524002

出　　处：《世界核心医学期刊文摘（眼科学分册）》2003年第1期521-522,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：目的 探讨^(99m)Tc-MIBI肿瘤显像定性检测恶性肿瘤组织P-糖旦白表达与化疗效果之间的关系方法 应用SPECT静态显像,以病灶区域^(99m)Tc-MIBI的潴留指数(RI)为P-GP定性指标,RI<O为P-GP阳性,将^(99m)Tc-MIBI定性测定的P-GP结果与化疗疗效比较。结果 22例原发及继发肝癌和肺癌患者中13例P-GP表达阳性(59.09％),化疗有效率15.35％;9例(40.91％)P-GP表达阴性,化疗有效率为77.78％。两组有效率比较有显著性差异(P<0.01).结论 ^(99m)Tc-MIBI恶性肿瘤显像可预测化疗效果。Objective To explore the connection of P-glycoprotein (p-gp) expression and the chemotherapeutic response rate in patients with carcinoma. Method 99mTc-MIBI imaging was performed on each patient with SPECT. Retention indices (RI) of 99mTc-MIBI at tumor sites were calculated and the negative value of R1 was defined as p-gp positive. P-gop expression was compared with the tumor response after chemotherapy. Results 22 patienls with carcinoma were included in this study. 13 patients were defined as p-gp positive (59. 09% ) and the chemothera-peutic response rate in these patients was 15. 35%. 9 patients were p-gp negative (40. 91%) and the chemother-apeutic response rate in these patients was 77. 78% . The response rate in patients with negative p-gp was much higher than that in patients with positive p-gp. Conclusion 99mTc-MIBI imaging may be employed predict the chemotherapeutic response in patients with carcinoma.

关 键 词：恶性肿瘤 多药耐药 放射性核素显像 化学疗法 

分 类 号：R730.4[医药卫生—肿瘤]