Pegaptanib治疗湿性老年性黄斑变性后视网膜色素上皮脱离  

Retinal Pigment Epithelial Tears After Pegaptanib Injection for Exudative Age-related Macular Degeneration

作　　者：Singh R.P. Sears J.E. 许娜 

机构地区：[1]Cole Eye Center,Cleveland Clinic Foundation,Cleveland Clinic Lerner Col-lege of Medicine,Cleveland,OH,United States Dr.

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第10期61-62,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：Purpose:To report two cases of retinal pigment epithelium(RPE)tears following intravitreal pegaptanib injections for occult choroidal neovascularization.Design:Noncomparative case series.Methods:The charts of two patients with pigment epithelial tears after receiving intravitreal pegaptanib were reviewed.Approval from the institutional review board and informed consent were obtained before chart review.Fundus photos,intravenous fluorescein angiograms,and optical coherence tomography(OCT)were obtained before and after therapy confirmed the diagnosis.Results:Two patients had turbid pigment epithelial detachments(PEDs)and occult choroidal neovascular membranes(CNVMs)treated with intravitreal pegaptanib.Both patients developed RPE tears weeks following one intravitreal pegaptanib injection.Conclusions:This report describes the development of RPE tears after intravitreal pegaptanib injection.Caution should be taken in cases of turbid pigment epithelial detachments in the monocular patient when treatment with intravitreal pegaptanib is entertained.Future studies should be performed to evaluate which subtypes of lesions are most susceptible to this devastating visual complication.Purpose:To report two cases of retinal pigment epithelium(RPE)tears following intravitreal pegaptanib injections for occult choroidal neovascularization.Design:Noncomparative case series.Methods:The charts of two patients with pigment epithelial tears after receiving intravitreal pegaptanib were reviewed.Approval from the institutional review board and informed consent were obtained before chart review.Fundus photos,intravenous fluorescein angiograms,and optical coherence tomography(OCT)were obtained before and after therapy confirmed the diagnosis.Results:Two patients had turbid pigment epithelial detachments(PEDs)and occult choroidal neovascular membranes(CNVMs)treated with intravitreal pegaptanib.Both patients developed RPE tears weeks following one intravitreal pegaptanib injection.Conclusions:This report describes the development of RPE tears after intravitreal pegaptanib injection.Caution should be taken in cases of turbid pigment epithelial detachments in the monocular patient when treatment with intravitreal pegaptanib is entertained.Future studies should be performed to evaluate which subtypes of lesions are most susceptible to this devastating visual complication.

关 键 词：视网膜色素上皮 PEGAPTANIB 老年性黄斑变性 脉络膜新生血管 眼底照相 荧光素 腔内注射 隐 

分 类 号：R774.5[医药卫生—眼科]