CD10,PR,Ki-67表达水平与子宫内膜间质肿瘤生物学特性的相关性研究  

Study on the expression and clinical-biological significance of CD10 antigens,progesterone receptions and Ki-67 nuclear antige in endometrial stromal tumors

作　　者：王刚平[1] 田胜花 梁粉花[1] 赵明春[1] 

机构地区：[1]日照市人民医院,山东日照276826

出　　处：《临床医药实践》2008年第S5期962-965,共4页Proceeding of Clinical Medicine

摘　　要：目的:探讨子宫内膜间质肿瘤(EST)中CD10、PR、Ki-67的表达水平与临床生物学特性的关系。方法:对9例子宫内膜间质结节(ESN)、24例子宫内膜间质肉瘤(ESS)和12例未分化子宫内膜肉瘤(UES)用免疫组化法检测CD10,PR,Ki-67的表达情况,并与临床表现及随访结果对照。结果:CD10,PR在ESN,ESS,UES中表达逐渐减弱,而Ki-67则逐渐增强,在ESS中阳性率分别为95.8%、38.0%,Ki-67指数为38%,与UES差异有统计学意义(P<0.05),而ESN与ESS间差异无统计学意义(P>0.05)。结论:EST生物学行为和预后可能与CD10、PR、Ki-67阳性表达的数量和强度有关;PR常规检测可作为判断预后的指标及指导孕激素辅助治疗。Objective:To study the expression of CD10,PR,and Ki-67 in endomertrial stromal nodule(ESN),endomertrial stromal sarcoma(ESS) and undifferentiated endometrial sarcoma(UES),and investigate their associations with clinical-biological characteristics.Methods:Immunohistochemical envision method was applied to detect the expression of CD10,PR,and Ki-67 expression in 9 cases of ESN,24 cases of ESS and 12 cases of UES,and the clinic-pathologic characteristics was analyzed.Results:The CD10,PR shown stronger intensity and amount positive in ESN and ESS than UES.Ki-67 nuclear antigen is in the otherwise.The positive rates of CD10,PR,and Ki-67 in ESS were 95.8%,38.0%,and Ki-67 were 38% which were higher than in UES(P<0.05).They were not related with age and site of tumor of patients(P>0.05).There was posive correlation of CD10,PR,and Ki-67 with histolegical grade and lymph node metastasis and distant metastasis between ESS and UES.Conclusion:The expression of CD10,PR and Ki-67 might be important biological markers for histolegical grade of EST.The detaction of PR is the predictor for prognosis and targeting treatment of ESS and UES.

关 键 词：子宫内膜间质肿瘤 临床 病理 CD10抗原 KI-67核抗原 

分 类 号：R737.33[医药卫生—肿瘤]