甲基强的松龙与地塞米松在治疗儿童喘息性疾病的比较临床分析  

A comparison between methylprednisolone and dexamethasone for the treatment of childhood asthmatic disorders

作　　者：欧文闻[1] 陈传贵[1] 陈光福[1] 

机构地区：[1]深圳市第二人民医院儿科

出　　处：《临床医药实践》2009年第3Z期1510-1512,共3页Proceeding of Clinical Medicine

摘　　要：目的:比较甲基强的松龙与地塞米松治疗儿童喘息性疾病的疗效。方法:102例喘息性疾病(包括喘息性支气管炎、支气管哮喘,除外支气管异物、支气管淋巴结核压迫及心源性哮喘等疾病)患儿随机分为两组;治疗组52例给予甲基强的松龙1～2mg/(kg·次),轻度喘息1次/天静滴,中、重度2次/天静滴;对照组50例给予地塞米松0.25～0.5mg/kg·次),用法同治疗组。结果:甲基强的松龙组与地塞米松组总有效率分别为96.2%与82%,经统计学处理,差异显著(x2=5.34,P【0.05)。甲基强的松龙治疗喘息性疾病疗效明显比地塞米松好。结论:甲基强的松龙治疗喘息性疾病疗效优于地塞米松。Objective:To compare the efficacy of methyl-prednisolone with that of dexamethasone(DXM)in the treatment of childhood asthmatic disorders.Methods:102 children suffering from asthmatic disorders(including asthmatic bronchitis and bron-chial asthma and excluding asthmas caused by a foreign body in bronchus and an oppression from bronchial lymphoid tuberculosis,and cardiac asthma)were randomly assigned to the study group(52cases)or the control group(50 cases),which were respectively given1～2mg/kg methylprednisolone or0.25～0.5mg/kg DXM by intravenous drip at 1 time per day for slight cases or 2 times per day for moderat to severe cases.Results:The total effective rates were 96.2% for the study group and 82% for the control group.According to statistical analysis,there was a significant difference between the groups(x2=5.34,P<0.05),suggesting that methyl-prednisolone is preferable for the treatment of asthmatic disorders.Conclusion:The efficacy of methylprednisolone is superior to that of DXM in the treatment of childhood asthmatic disorders.

关 键 词：喘息性支气管炎 支气管哮喘 甲基强的松龙 地塞米松 

分 类 号：R725.6[医药卫生—儿科]