低分子肝素治疗短暂性脑缺血发作的疗效观察  

Curative Effect Observation On Treatment of TIA with Low Molecular Heparin

作　　者：郭建华[1] 朱涛[1] 

机构地区：[1]江苏省徐州医学院附属第三医院神经内科,221003

出　　处：《临床医药实践》2009年第11X期857-859,共3页Proceeding of Clinical Medicine

摘　　要：目的:观察低分子肝素治疗短暂性脑缺血发作(TIA)的效果。方法:57例TIA患者,随机分为观察组和对照组,观察组给予低分子肝素钠5000IU皮下注射,每12h1次,共10d,对照组给予肠溶阿司匹林100mg口服,每日1次,观察发作次数及纤维蛋白原(FIB)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)的变化。结果:疗程结束观察组显效率69.0%,而对照组显效率32.1%,两组差异有统计学意义(P<0.01),治疗前后FIB、PT、APTT变化不明显,无出血等并发症。结论:低分子肝素治疗TIA有效且安全性好。Objective:To study the effect of low molecular weight heparin(L MWH)in treatment of transient ischemic attack (TIA). Methods:Fifty-seven patie nts were randomly divided treatment group and control group.The treatment g roup were injected LMWH 5000 IU once every 12 hours for 10 days, while the control group were given asprine 100 mg orally once a day.The times of attack and the changes of fibrinogen(FIB),prothrombin tim (PT) and activated partial thromboplastin time (APTT) were observed. Results:The markedly effective rates were 69.0% and 32.1% in the treatment group and the control group respectively. The difference was significant. There were no significant differences between FIB, PT and APTT,before and after treatment. No hemorrhage or other complications occurred. Conclusions:LMWH is effective and safe for treatment of TIA.

关 键 词：暂时性 脑缺血 低分子肝素 纤维蛋白原 

分 类 号：R743.3[医药卫生—神经病学与精神病学]