OFL方案治疗晚期结直肠癌的临床观察  

作　　者：孔凡龙[1] 韩建国[1] 郭志峰[1] 杨艳[1] 王小林[1] 

机构地区：[1]赤峰市医院肿瘤内科,内蒙古赤峰024000

出　　处：《临床医药实践》2010年第7X期898-899,共2页Proceeding of Clinical Medicine

摘　　要：目的:观察OFL方案治疗晚期结直肠癌的临床疗效及安全性。方法:采用奥沙利铂(L-OHP)130mg/m2,静脉滴注2h,第1天;亚叶酸钙(Lv)200mg/次,静脉滴注2h,第1-5天;5-氟尿嘧啶(5-FU)400mg/m2,静脉注射,第1-5天的方案治疗48例晚期结肠癌患者。3w为1周期,重复4周期。观察患者疗效和不良反应。结果:全组48例,CR1例(2.1%),PR17例(35.4%),SD14例(29.2%),PD16例(33.3%),总有效率为37.5%,疾病控制率66.7%。不良反应主要为神经毒性、胃肠道反应、脱发和粒细胞下降,多呈I-Ⅱ度,可耐受。结论:OFL方案治疗晚期结肠癌安全有效,患者耐受性良好,值得临床推广。Objective:To evaluate the efficacy and toxicity of the protocol of OFL for advanced colorectal cancer.Methods:Oxaliplatin 130 mg/m2,ivdrip,2h,d1;LV 200 mg/time,ivdrip,2h,d1-5;5-FU 400 mg/m2,ivdrip,4-6h,d1-5.Four courses were carried out with an interval of three weeks.Results:48 patients:CR 1 case(2.1%),PR 17 cases(35.4%),SD 14cases(29.2%),PD 16 cases(33.3%).The overall response rate was 37.5%.The major toxicities were neurotoxicity,suppression of bone marrow,gastrointestinal toxicity and most of which I-II grad.Conclusion:OFL regimen can be regarded as an effective regimen for advanced colorectal cancer,and its toicity is tolerable.Worthy to further clinic study.

关 键 词：晚期结直肠肿瘤 化学疗法 奥沙利铂 

分 类 号：R735.3[医药卫生—肿瘤]