Neurotropin治疗缺血性脑卒中的疗效观察  

Observation on Treatment of Neurotropin to Ischemic Stroke

作　　者：翟宇[1] 金嘉翔[1] 朱宁[1] 陆勤[1] 石楠[1] 刘德海[2] 

机构地区：[1]上海第二医科大学第九人民医院神经内科,上海200011 [2]上海第二医科大学第九人民医院放射科,上海200011

出　　处：《上海第二医科大学学报》2002年第5期450-452,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：目的研究neurotropin治疗急性缺血性脑卒中的可行性和有效性。　方法对 5 0例发病 4 8h内 ,神经功能评分 <80分 ,病灶面积 >2 .2 5cm2 的急性颈内动脉梗塞的患者进行随机分组试验 (neurotropin治疗组 31例 ,对照组 19例 )。测定治疗前后不同阶段神经功能缺损评分、日常生活能力、CT病灶面积和平均CT值 ,并进行统计学分析。　结果治疗组神经功能改善率为 6 4 .5 % ,对照组为 31.6 % ;11d时梗塞水肿面积治疗组已缩小 2 8.8% ,且平均CT值明显提高 ,改善程度明显优于对照组。Objective To study the feasibility and efficiency of neurotropin in treatment to patients with acute moderate and severe ischemic stroke. Methods Randome control trial of neurotropin was performed in 50 patients admitted within 48h after acute internal carotid artery infarction. As neurological deficits score (Europe Stroke Scale, ESS)<80 and the area of infarct and edema>2.25cm 2, all patients were divided in neurotropin group(31) and control group(19). We evaluated ESS, ability of daily living (ADL)-Barthel index, and the size and average CT density of infarct and edema area. Results The percentage of improved patients (complete and partial recovery) reaches 64.5% in the neurotropin group and 31.6% in the control group. The size of the infarct and edema area on CT scan significantly reduced only in the neurotropin group after treatment, which reduced to 28% on d11. The average CT density in the neurotropin group improved much more than in the control group. Conclusion Neurotropin can be used as an effective therapy in acute ischemic stroke and ischemic cerebral edema.

关 键 词：缺血性脑卒中 脑水肿 NEUROTROPIN 疗效观察 治疗 

分 类 号：R743[医药卫生—神经病学与精神病学]