大肠癌门静脉插管化疗预防肝转移  

Preventing Hepatic Metastasis by Port Vein Infussion on the Patients with Large Bowel Cancer

作　　者：葛自新[1] 尤其邑[1] 王华[1] 张春辉[1] 陈拓[1] 倪启超[1] 姚健[1] 

机构地区：[1]南通医学院附属医院,226001

出　　处：《交通医学》2002年第5期510-512,共3页Medical Journal of Communications

摘　　要：目的 :探讨大肠癌根治术门静脉插管 5 -Fu化疗预防肝转移的疗效。方法 :87例DukesB、C期大肠癌患者 ,随机双盲分组 :根治性切除加门静脉化疗 45例 (治疗组 )及单纯根治性切除 42例 (对照组 )。治疗组于根治术当日即以 5 -Fu 1g持续 2 4小时门静脉滴注化疗 7天 ;对照组住院期间不作辅助化疗。结果 :治疗组肝转移发生率明显低于对照组 ,DukesC期术后 3 ,5年生存率也显著高于对照组 ,DukesB ,期无明显差异。结论 :大肠癌根治术门静脉插管预防性化疗 ,可有效降低肝转移的发生率 ,提高DukesC期患者 3、5年生存率。Objective:To investigate the effect of the chemotherapy by port vein infussion (PVI) to prevent hepatic metastasis on the patients with large bowel cancer.Methods:After radical resection ,87 patients with large bowel cancer were randomly divided into 2 groups, the therapy group received 5-Fu (1.0g/d, continued 7d) chemotherapy by PVI the poeration day. The control group did not receive any chemotherapy during the time in the hospital.Results:The rate of liver metastasis in the therapy group was lower than in the control group and the rate of 3 and 5-year-survival had no difference in stage Dukes B, but it was higher in the chemotherapy of PVI group than the control group in stage Dukes C.Conclusions:5-Fu chemotherapy by PVI after radical resection in the patients with large bowel cancer may decrease the liver metastasis rate and raise the 3 and 5-year-survival rate in stage Dukes C.

关 键 词：预防 肝转移 大肠癌 门静脉插管化疗 DUKES分期 

分 类 号：R735.34[医药卫生—肿瘤] R730.53[医药卫生—临床医学]