人体正常组织内pRb2/p130的表达及意义  

Expressions and significances of pRb2/p130 in normal human tissues

作　　者：郑素勤[1] 孙瑞军[1] 张玉强[1] 荣玲[1] 王献华[1] 王利民[2] 

机构地区：[1]华北煤炭医学院基础部病理教研室,河北唐山063000 [2]华北煤炭医学院附属医院,河北唐山063000

出　　处：《华北煤炭医学院学报》2002年第5期550-552,共3页Journal of North China Coal Medical College

摘　　要：①目的 检测人体正常组织内pRb2/p130的表达,为探讨pRb2/p130的表达与人体恶性肿瘤病理分级、临床分期和预后的关系做基础研究。②方法 应用免疫组化SP法检测pRb2/p130在各种正常人体组织内的表达(38种,每种10例,共计380例)。③结果 pRb2/p130蛋白普遍存在于正常组织内,但在不同的组织其表达水平不尽相同,其中以肺支气管上皮细胞、肾集合管上皮细胞、淋巴细胞、单核细胞的表达水平最高,皮肤的鳞状上皮细胞、肺支气管壁的腺细胞、食管和胃等器官的上皮细胞内表达水平较高。脂肪细胞不表达。④结论 pRb2/p130蛋白是一种抑癌基因的表达蛋白,在人体正常组织细胞中具有广泛的表达,可用于恶性肿瘤组织的检测。Objective In this study,we detected the expression of pRb2/p!30 in normal human tissues,preparing for the study of the expression of pRb2/p!30 in human malignant cancer. Methods Using imunohistochemical techniques,we examined a variety of normal human tissues for the expression of pRb2/p130. Results pRh2/p130 was ex pressed ubiquitously, although different tissue levels of expression were found in various tissues and cells, such as bronchi epithelia, kidney collecting ducts , lymphocyte and monocyte , showed high expression levels for pRb2/p130. whereas it shows middle levels in cells,such as the epithelia of skin,bronchi gland,esophagus or stomach,and there is no expression in fat cell. Conclusion pRb2/p130, which was the products of Rb2 (tumor surpressor gene),was expressed ubiquitously in normal human tissues. We can study the levels of expression of Rb2/pl30 in human malignant tumor.

关 键 词：PRB2/P130 免疫组织化学 正常人体组织 抑癌基因 恶性肿瘤 临床意义 

分 类 号：R730.2[医药卫生—肿瘤]