喉鳞癌中P53表达与意义  

The Expression of P53 in Laryngeal Squamous Cell Cancer and Its Clinical Significance

作　　者：王建中[1] 黄新生[1] 黄凤娥[1] 吴钦苏[1] 常荣先[1] 

机构地区：[1]复旦大学附属中山医院耳鼻喉科,上海200032

出　　处：《中国临床医学》2002年第4期353-354,共2页Chinese Journal of Clinical Medicine

摘　　要：目的 :研究喉鳞癌中P5 3表达与意义。方法 :应用免疫组织化学方法 (Envision) ,检测 6 3例喉鳞癌、7例喉乳头状瘤、10例声带息肉组织中P5 3基因蛋白的表达。结果 :(1)P5 3在上述三种组织中表达率分别为 5 1%、2 8%、0 % ,差异有统计学意义(P <0 .0 1) ;(2 )P5 3表达与喉鳞癌病理组织分级及临床分期 (TNM )相关 ,P5 3阳性表达者 ,其肿瘤组织病理分级差 (P <0 .0 5 ) ,Ⅰ、Ⅱ期肿瘤阳性表达率低于Ⅲ、Ⅳ期 (P <0 .0 5 ) ;(3)P5 3阳性表达与颈淋巴结转移无关 (P >0 .0 5 )。结论 :P5 3在喉上皮中的表达与其恶性程度相关 ,P5 3表达者其预后可能不良。Objective: In order to study the relationship between the expression of P53 in laryngeal squamous cell cancer and its clinical significance. Methods: The immunohistochemistry method was used to detect the expression of P53 in Sixty three cases of laryngeal squamous cell cancer (LSCC), seven cases of laryngeal papilloma and ten cases of polyp of vocal cord. Results: 1. The expression rate of P53 in the above three tissues was 51%, 28%, 0% respectively, and the difference was statistically significant ( P <0.05) . 2. The P53 expression in LSCC was related to the degree of cell differentiation and TNM category ( P <0.05). Conclusion: The expression of P53 were related to the degree of malignance in laryngeal epithelial cell, and the expression of P53 may be identified as an objective indicator of LSCC patients with a poor prognosis.

关 键 词：表达 喉肿瘤 免疫组织化学 P53 

分 类 号：R739.65[医药卫生—肿瘤]