速效醒脑滴丸的提取工艺研究  

Study on the Technology for Preparing Suxiaoxingnao Gutta Pills

作　　者：王玉蓉[1] 吴清[1] 王晓强[1] 任天池[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《北京中医药大学学报》2002年第5期43-46,共4页Journal of Beijing University of Traditional Chinese Medicine

摘　　要：探讨速效醒脑滴丸中川芎的提取工艺。采用渗漉法提取川芎中有效部位 ,用正交设计法对提取溶媒(乙醇 )的浓度、用量及浸泡时间进行实验考察 ,以高效液相色谱 (HPLC)法测定川芎主要有效成分阿魏酸、川芎嗪的含量 ,筛选出最佳提取工艺。结果表明用 70 %乙醇、浸泡 2 4h、溶媒量 8倍的渗漉条件阿魏酸。The technology of extracting the active components from Chuanxiong (the dried rhizome of Ligusticum chuanxiong) in preparing Suxiaoxingnao Gutta Pills was investigated. The technique of percolation was used to extract the active components from Chuanxiong; the concentration and the amount of the percolation solvent (alcohol) and the time for the immersion of Chuanxiong in the solvent were determined by the orthogonal design; and HPLC was used to determine the contents of ferulic acid and ligustrazine, the two main active components of Chuanxiong. The results showed that ferulic acid and ligustrazine in the extract could reach their highest concentrations when being extracted by percolation on condition that the 70% alcohol was used as percolation solvent, the time for the immersion of Chuanxiong was 24 hours, and the amount of percolation solvent was 8 times the amount of the crude drug.

关 键 词：速效醒脑滴丸 提取工艺 研究 阿魏酸 川芎嗪 高效液相色谱法 

分 类 号：R284.2[医药卫生—中药学]