低分子肝素用于溃疡性结肠炎抗炎干预中的可行性分析  

Low molecular weight heparin as anti-inflammatory intervention for ulcerative colitis

作　　者：王溶[1] 

机构地区：[1]四川宜宾市第三人民医院消化内科,四川宜宾644000

出　　处：《结直肠肛门外科》2015年第6期418-421,共4页Journal of Colorectal & Anal Surgery

摘　　要：目的探析低分子肝素在溃疡性结肠炎抗炎干预中的应用可行性。方法以2011年1月至2014年12月共收治107例溃病性结胸炎(UC)作为研究对象,随机分为观察组(54例)与对照组(53例),对照组予以常规治疗,观察组在对照组基础上应用低分子肝素,比较两组治疗前后炎症因子指标CRP、内镜指数EI、DAI、凝血指标PT、APTT、D-dimer、TT、治疗总有效率、复发率、不良反应发生率。结果两组治疗前CRP、内镜指数EI及DAI的差异均P﹥0.05,治疗后观察组CRP、内镜指数EI及DAI均低于治疗前及对照组治疗后,差异P﹤0.05。两组治疗前各项凝血指标的差异均P﹥0.05,治疗后观察组PT、APTT、D-dimer、TT等凝血指标均低于治疗前及对照组治疗后,差异P﹤0.05。观察组治疗总有效率为84.2%(46/54),高于对照组62.3%(33/53),差异P﹤0.05;观察组不良反应发生率为11.1%(6/54),复发率为3.7%(2/54),与对照组7.5%(4/53)及5.7%(3/53)相比,差异均P﹥0.05。结论低分子肝素在溃疡性结肠炎抗炎干预中的应用可强化抗炎效果的同时发挥抗凝、抗血栓作用,利于疾病恢复,且安全性高,具有较大可行性,值得借鉴。Objective To investigatethe efficacyof low molecular weight heparin in anti-inflammatory intervention for ulcerative colitis(UC).Methods A total of 107 patients with UC who were treated between January 2011 and December 2014 were recruited as study subjects.Using random number table method,they were assigned totreatment group(54 cases) and control group(53 cases).Patients in control group received routine treatment and patients intreatment groupreceived low molecular weight heparin in addition to routine treatment.Inflammatory factor including C-reactive protein(CRP),endoscopic index(EI),and DAI,coagulation index including PT,APTT,D-dimer,and TTbefore and after treatment,total effective rate of treatment,recurrence rate,and incidence of adverse reactions in the two groups were compared.Results The differences of CRP,EI,and DAI between the two groups before treatment were not significant(P >0.05).After treatment,in the treatment group,CRP,EI and DAI were lower than those before treatment and were lower than those in the control group after treatment(P <0.05).The differences of coagulation indexes between the two groups before treatment were not significant(P > 0.05).After treatment,in the treatment group,PT,APTT,D-dimer,TT and other blood coagulation indexes were lower than those before treatment and were lower than those in the control group after treatment(P <0.05).The total effective rate in the treatment group(84.2%,46/54) was higher than that in the control group(62.3%,33/53)(P <0.05).The incidence of adverse reactions and recurrence rate in the treatment groupwere11.1%(6/54) and 3.7%(2/54),respectively,while those in the control group were 7.5%(4/53) and 5.7%(3/53),respectively(P >0.05).Conclusions Low molecular weight heparin as an anti-inflammatory intervention forulcerative colitis can strengthen the anti-inflammatory effect and play an anticoagulant and antithrombotic role at the same time.It is feasible and effectivefor diseaserecovery with high safety profile.It holds great clinical potential.

关 键 词：溃疡性结肠炎 抗炎 血液高凝 低分子肝素 

分 类 号：R574.62[医药卫生—消化系统]