内镜粘膜切除治疗癌前病变和早期食管癌  

Endoscopic mucosectomy on precancerous lesions and early esophageal cancer

作　　者：王国清[1] 郝长青[2] 王贵齐[1] 吕宁[3] 林冬梅[3] 谢永强[3] 赖少清[1] 

机构地区：[1]100021,北京中国医学科学院肿瘤医院内镜科 [2]河南省林州市肿瘤医院内镜科 [3]100021,北京中国医学科学院肿瘤医院病理科

出　　处：《中华消化内镜杂志》2002年第4期218-220,共3页Chinese Journal of Digestive Endoscopy

基　　金：美国国立癌症研究所资助(No2-Sc-45586)

摘　　要：目的 评价内镜粘膜切除术治疗癌前病变和早期食管癌的效果,并对其适应证、手术操作和并发症等进行临床研究。方法 从食管癌高发现场的普查和门诊工作中发现的病例,选择符合内镜粘膜切除适应证者,在镇静麻醉下完成154例内镜粘膜切除术。对术中发生的一些并发症进行了认真观察和处理。结果 完成154例内镜粘膜切除术,发生创面小动脉出血发生18例（11.7％）,食管穿孔2例（1.3％）,经处理后均顺利痊愈。结论 内镜粘膜切除术是治疗食管鳞状细胞原位癌、粘膜内癌和癌前病变的重要治疗方法。Objective To evaluate the efficacy of endoscopic mucosectomy on the precancerous lesions and early esophageal cancer, and to study its indication, procedure and complication. Methods One hundred and fifty four cases who was eligible for mucosectomy from mass screening at high risk area of esophageal cancer and out-patients department underwent endoscopic mucosa! resection with sedation anesthesia. Some complications which occurred during endoscopic therapy were observed and treated seriously. Results Endoscopic mucosal resection was fulfilled in 154 cases. Arteriolar hemorrhage from the wound, 11.7% and esophageal perforation, 1.3% happened. All of them were cured uneventfully. Conclusion Mucosectomy is of value in the endoscopic treatment of carcinoma in situ, intramucosal carcinoma and precancerous lesions . Endoscopic mucosectomy should be widely used. E-sophageal perforation can be expected with conservative treatment. The indication and EMR procedure were discussed in detail.

关 键 词：粘膜切除术 早期 食管癌 癌前病变 

分 类 号：R735.1[医药卫生—肿瘤]