甲状腺肿瘤PCNA免疫组化的定量研究  

Immunohistochemistry and its image analysis study of PCNA in thyroid tumours

作　　者：孙青[1] 高钟禹[1] 鹿伟[1] 吴彩志[1] 张传森[1] 

机构地区：[1]山东省千佛山医院病理科

出　　处：《中国体视学与图像分析》1998年第4期228-229,共2页Chinese Journal of Stereology and Image Analysis

摘　　要：应用免疫组化和图像分析技术对甲状腺腺瘤及各型癌中ＰＣＮＡ的分布和相对含量进行了定量病理学研究。结果显示，ＰＣＮＡ阳性表达的平均指数以及平均光密度和积分光密度变化与肿瘤的良恶性及恶性程度呈正比，各参数间均有极显著差异（Ｐ＜００１）。ＰＣＮＡ平均指数和图像分析可作为肿瘤鉴别诊断和估价预后的指标。The immunohistochemistry,image analysis and pathological morphology of proliferating cell nuclear antigen (PCNA) were studied in thyroid adenoma and carcinoma.The results showed that PCNA mean index(MI),mean optical density(MOD)and integrated optical density(IOD)were significantly different between adenoma and carcinoma,and various histological types of carcinomas (P<0 01).The positive expression rates of PCNA were parallelly proportional to the malignant degree of thyroid tumors.So MI and image analysis of PCNA may be useful indicators for the differential diagnosis of thyroid tumors and their prognosis assessment.

关 键 词：甲状腺肿瘤 PCNA 免疫组化 图像定量分析 

分 类 号：R736.1[医药卫生—肿瘤]