甲状腺滤泡性肿瘤形态定量分析  

Morphometric analysis of thyroid follicular tumours

作　　者：王炼[1] 刘正明[1] 方一心 吴兰雁 王开平 

机构地区：[1]华西医科大学病理学教研室 [2]华西医料大学组织胚胎学教研室,成都,610041 [3]华西医科大学口腔病理教研室,成都,610041 [4]四川联合大学计算机系

出　　处：《中国体视学与图像分析》1996年第1期74-76,共3页Chinese Journal of Stereology and Image Analysis

基　　金：国家自然科学基金

摘　　要：本文应用MIAS-300型图像分析系统对甲状腺良、恶性滤泡性肿瘤各30例及正常甲状腺组织8例进行了形态定量测定及比较分析,旨在探寻形态定量指标在鉴别诊断中的价值,并建立数据库,为计算机协助诊断疾病打下基础。常规制片,用个体测量法及群体测量法分别分析了每例100～145个滤泡上皮细胞,获得6项参数,包括核面积、核周长、核形状因子、等效核直径、核黑度及核质比。经统计学分析,显示上述各项参数在良恶之间比较均有高度显著性差异,表明这些参数在甲状腺滤泡性肿瘤良恶鉴别中有一定价值,为数学病理学研究提供了一定资料。A retrospective analysis of surgically resected thyroid tumours including 30 follicular adenomas (FA), 30 follicular carcinomas (FC) and 8 normal thyroid glands was performed by morphometric analysis with MIAS-300 image analysis system. One hundred to 145 tumour cell nuclei were studied per case for their area, perimeter, regular form factor, equivalent diameter, darkness and the ratio of nuclear area to cytoplasmic area. Highly significant statistical difference was detected in every parameter between benign and malignant cases. The result suggests that morphometric analysis of these parameters is of some value to the differential diagnosis of benign and malignant follicular thyroid tumours.

关 键 词：甲状腺肿瘤 滤泡性腺癌 鉴别诊断 图像分析 

分 类 号：R736.1[医药卫生—肿瘤]