肝癌细胞核形态的分形分析  

Fractal analysis of cell nucleus of liver carcinoma

作　　者：张中华[1] 徐元鼎[1] 

机构地区：[1]上海医科大学基础医学院病理教研室,上海200032

出　　处：《中国体视学与图像分析》1996年第1期81-84,共4页Chinese Journal of Stereology and Image Analysis

摘　　要：本文在肿瘤细胞核形态的研究中引入分形论,选择临床上常见的肝癌,在电镜下观察肿瘤细胞核的形态,通过分形图像处理系统,采用数盒子的方法计算细胞核边界的分维值,数据的统计采用t检验在EPI-5统计软件上进行。结果发现:肝癌和正常肝细胞核边界的分维值大于其拓扑维值1（P<0.01）,即它们是分形结构。肝癌细胞核边界的分维是1.162±0.032,大于正常肝细胞核的边界分维1.060±0.017（P<0.00001）。上述研究表明:在电镜观察下（放大倍数5000-12000倍）肿瘤细胞核的形态是分形结构;分维定量地描述了肿瘤细胞核形态的不规则程度,对肿瘤病理良恶性的鉴别具有一定意义。In this research fractal geometry was used to analyse the nuclear shape of liver carcinoma. The nuclei of liver carcinoma were observed under the electron microscope (EM). The fractal dimension of the nuclear boundary was measured through box-counting method implemeted on a fractal image process system(FIPS). Results were evaluated using t test on the epi-5 statistical software. This study showed that the mean fractal dimension of cell nucleus of liver carcinoma and normal liver cells were significantly greater than their topological dimension of 1(,P<0. 01). So their nuclear boundaries are fractal structures. The fractal dimension of nucleus of liver carcinoma was significantly greater than that of the normal liver cells (1. 162 vs 1. 060, P<0. 00001). These results indicated that the nucleus of the tumor cell, when observed under EM (the magnification was between 5000 and 12000), have a fractal structure. Fractal dimension is a better way of quantitating the extent of nuclear shape irregularity and an useful morphological discriminant between the malignant and normal cells.

关 键 词：肝癌 细胞核 形态 分形 

分 类 号：R735.7[医药卫生—肿瘤]