甲状腺肿瘤的DNA定量研究  

Research on DNA quantitation of thyroid tumor

作　　者：孙青[1,2] 高钟禹[1,2] 鹿伟[1,2] 吴彩志[1,2] 张传森[1,2] 

机构地区：[1]山东省千佛山医院病理科 [2]第一军医大学病理教研室

出　　处：《中国体视学与图像分析》1997年第3期151-153,共3页Chinese Journal of Stereology and Image Analysis

基　　金：山东省卫生厅科研课题

摘　　要：利用图像分析系统（ＩＣＭ）对７７例甲状腺腺瘤、不典型腺瘤及各型癌进行检测。结果显示腺瘤同不典型腺瘤比较，ＤＮＡ指数无明显区别（Ｐ＞００５）；两者与癌比较则具有显著性差异（Ｐ＜００１）。ＤＮＡ倍体分析结果表明，腺瘤、不典型腺瘤以及乳头状腺癌在３－４ｃ处形成主峰值，而滤泡癌、髓样癌及未分化癌倍体直方图明显右移，主峰位居＞５ｃ处。不典型腺癌与滤泡癌比较，无论ＤＩ值还是ＤＮＡ倍体值均有显著性差异（Ｐ＜００１），表明ＤＮＡ图像分析可为甲状腺肿瘤的鉴别诊断提供定量依据，并可作为判断肿瘤恶性程度的重要指标。cases of thyroid neoplasms such as thyroid adenoma, atypical adenoma and thyroid carcinoma were investigated respectively with a real color image analysis system. The results showed that the mean DNA index between adenoma and atypical adenoma was not statistically different (p>0 05), but there was significantly different to the thyroid carcinomas (p<0 01). By the DNA genome histogram, all of adenoma, atypical adenoma and papillary carcinoma showed peak values at 3-4C, while, all of follicular carcinoma, madullary carcinoma and undifferentiated carcinoma showed a significant right-shift peak over 5C. Both DI and DNA genome values of atypical adenoma VS follicular carcinoma were significantly different. This study demonstrates that DNA image analysis plays an important role in differentiating thyroid tumors quantitatively. Furthermore, it may be regarded as an indicative index to estimate malignant degree of thyroid carcinoma.

关 键 词：甲状腺肿瘤 鉴别诊断 DNA 图像分析 

分 类 号：R736.1[医药卫生—肿瘤]