肝细胞癌变的形态计量及其预后的关系  

A morphometrical analysis of hepatocarcinoma and its significance of prognosis

作　　者：韩枋[1] 王能进[1] 张建兵[1] 吴丽华[1] 杨书云[1] 郭燕[1] 曹松[1] 许炳华 

机构地区：[1]南通市肿瘤医院

出　　处：《中国体视学与图像分析》1997年第3期177-179,共3页Chinese Journal of Stereology and Image Analysis

摘　　要：为探索肿瘤细胞核形态计量对病理诊断和预后的意义，本文对有随访的３０例肝癌作形态计量分析显示：肝癌细胞核（核面积、周长、等效圆直径）较肝细胞明显增大，Ｐ＜００５；细胞核的形态亦明显较肝细胞不规则（核凸包比、形状因子），Ｐ＜００５；同时上两类参数的离异系数ＣＶ亦有明显差异。ＣＯＸ分析表明癌细胞核各项参数、癌瘤的直径及其组织学分级与患者术后存活时间有关。In order to evaluate the significance of the morphometry in th field of the pathological diagnosis of cancer and its prognosis, thirty cases of hepatocarcinoma with the following information were studied morphometrically in this series. It was showed that the nuclear size (area, perimeter, and DCIRCL parameters) of cancer cells was larger than that of normal hepatocytes, P<0 05, and the irregularity (convex rate and form factor) of cancer cells was more predominant than normal liver cells, P<0 05. The cox analysis suggested that morphometrical parameters of the hepatocarcinoma, area, perimeter, convex rate, form factor, DCIRCL size of cancer cells and histological grade, were related to the survival time.

关 键 词：肝细胞癌 形态计量 预后 

分 类 号：R735.7[医药卫生—肿瘤]