Bcl-2、CD44在肺癌组织中的表达及意义  

Study on expression of Bcl-2 and CD44 in human lung cancer

作　　者：樊再雯[1] 万毅新[2] 安真光[2] 张珍祥[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院呼吸疾病研究室,武汉430030 [2]兰州医学院第二附属医院呼吸科

出　　处：《肿瘤防治研究》2002年第5期373-375,共3页Cancer Research on Prevention and Treatment

摘　　要：目的　探讨Bcl 2、CD4 4s及CD4 4v6在肺癌中的表达情况及其与肺癌预后及转移的关系。方法　以SP法研究 83例原发性肺癌及 16例肺良性疾患。结果　Bcl 2、CD4 4s及CD4 4v6在肺癌组织中表达显著升高 (P <0 .0 1或P <0 .0 5 ) ,且表达强度与肺癌类型及临床分期有关 (P <0 .0 1) ,但与肺癌的分化程度无关 (P >0 .0 5 )。结论　Bcl 2可能参与了肺癌的发生发展过程 ,并可作为肺癌预后的一个指标。CD4 4v6阳性可能对肺癌转移及临床分期起一定作用。Objective To explore the relationship of the expression of Bcl\| 2, CD44s and CD44v6 with the oncogenesis , development and aggression of lung cancer.Methods Streptavidin\| peroxidase conjugated method (SP) were used for detecting those proteins in 16 benign bronchus\| lung diseases and 83 lung tumors. Results The expression levels of Bcl\| 2, CD44s and CD44v6 respectively were significantly higher in lung cancers than in benign bronchus\|lung diseases ( P <0.01 or <0.05).No relationship was observed between differentiation grade of lung cancer cell and expression of these protein( P >0.05).Conclusion (1) The proto\|oncogene Bcl\|2 may be involved in the oncogenesis and development of lung cancer, and its expression may become an important indicator in the prognosis of lung cancer.(2) CD44v6 may have a action on deciding TNM stage and aggression of lung cancer.

关 键 词：BCL-2基因 CD44 肺癌 基因表达 预后 肿瘤转移 临床分期 组织学 

分 类 号：R734.2[医药卫生—肿瘤]