伽玛刀加体外照射治疗脑转移瘤疗效观察  

An analysis of treatment result for brain metastasis of stereotactic radiosurgery plus radiotherapy

作　　者：冯纪祥[1] 任庆荣[1] 徐崇明[1] 张九成[1] 

机构地区：[1]湖北省肿瘤医院第二住院部,武汉430079

出　　处：《肿瘤防治研究》2002年第5期394-395,共2页Cancer Research on Prevention and Treatment

摘　　要：目的　观察脑转移瘤采用伽玛刀加体外照射 (SRS +R)及单纯放疗 (R)的临床效果。方法　 1995年 5月～ 2 0 0 0年 12月 ,38例脑转移瘤患者行SRS +R治疗 ,中心剂量 5 0～ 6 0Gy ,周边剂量 2 0～ 2 5Gy ,全脑外照射 30～ 4 0Gy/ 3～ 4周。 4 6例R治疗 ,全脑照射同前 ,缩野追加至 4 0～ 6 0Gy。 结果　中位生存期、1年生存率、肿瘤局部控制率 ,SRS +R组分别为 10月、6 0 .5 %及 92 .1% ;R组分别为 5 .3月、17.4 %及 2 1.7% (P <0 .0 1)。结论　SRS +R治疗脑转移瘤在延长患者生存期及肿瘤局部控制率明显优于R组。Objective To compare the effect in the treatment of brain metastasis between stereotatic radiosurgery puls radiotherapy (SRS+R) and radiotherapy (R) alone. Methods From May 1995 to December 2000, a total of 84 patients with brain metastasis were evaluated in this study . In SRS+R group, 38 patients were given SRS with the center dose of 50～60Gy and the bound dose of 20～25Gy, whole brain irradiation were given the dose of 30～40Gy in 3～4 weeks. In R group , 46 patients received a total dose of 40～60Gy with 30～40 Gy entire brain irradiation puls a boost of 10～20Gy. Results The median survival period were 10 months in SRS+R group and 5.3 months in R group. The one year survival rate were 60.5%(23/38) and 17.4%(8/46) in SRS+R group and in R alone group ( P <0.01). The local control rate were 92.1%(35/38) and 21.7%(18/46) in SRS+R group and R alone ( P <0.01). Conclusion SRS is superior to R alone in prolong the survival period and local control treatment of brain metastasis.

关 键 词：体外照射 疗效 伽玛刀 脑转移瘤 

分 类 号：R739.41[医药卫生—肿瘤]